力学刺激在椎体软骨终板退变中的作用及机制  

The Role and Mechanisms of Mechanical Stimulation in Degeneration of Vertebral Cartilage Endplates

作　　者：孙尚 赵振达 蒋嫒 刘忠军[1] 李危石 宋纯理 冷慧杰[1] SUN Shang;ZHAO Zhenda;JIANG Ai;LIU Zhongjun;LI Weishi;SONG Chunli;LENG Huijie(Department of Orthopedics,Peking University Third Hospital,Beijing 100191,China;Engineering Research Center of Bone and Joint Precision Medicine,Ministry of Education,Beijing 100191,China;Beijing Key Lab of Spine Diseases,Beijing 100191,China)

机构地区：[1]北京大学第三医院骨科,北京100191 [2]教育部骨与关节精准医学工程研究中心,北京100191 [3]北京脊柱疾病重点实验室,北京100191

出　　处：《医用生物力学》2021年第4期652-657,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(11872076,11472017)。

摘　　要：终板的重要功能是传递应力和供给营养。终板退变可能会诱发或促进椎间盘退变,引起一系列严重影响人们健康和生活质量的脊柱疾患。终板软骨细胞可以感受力学刺激。力学刺激是影响终板退变的重要因素,不适宜的力学刺激会加速终板退变。本文回顾力学刺激对终板软骨细胞凋亡、合成抑制、钙化及细胞外基质降解诸方面的影响,并总结力学刺激导致椎体终板退变的相关机制。力学刺激诱发的终板退变是由各种信号转导因子构成的复杂信号通路网络精细调节,包括NF-κB、Wnt、Hedgehog、MAPK、Rho A/Rock-1、AKT/m TOR、TGF-β、miRNA相关信号通路。同时,本文对这些通路相互联系进行梳理总结。多个信号通路可以共同作用调节终板软骨细胞代谢,并导致终板退变。本文希望通过相关机制系统回顾,给终板退变早期诊断及针对性治疗带来有益的启示。The important function of the endplate is to transmit stress and supply nutrition.Endplate degeneration might induce or promote degeneration of the intervertebral disc,causing a series of spine diseases that seriously impair people’s health and life quality.Endplate chondrocytes can respond to mechanical stimulation,which is an important factor affecting endplate degeneration.Inappropriate mechanical stimulation will accelerate endplate degeneration.This review summarized the effects of mechanical stimulation on vertebral endplate chondrocyte apoptosis,synthesis inhibition,calcification,and extracellular matrix degradation.The endplate degeneration induced by mechanical stimulation is regulated by a complex network of signal pathways composed of various signal transduction factors.The signal pathways involved in this review included NF-κB,Wnt,Hedgehog,MAPK,Rho A/Rock-1,AKT/mTOR,TGF-βsignaling pathway and miRNA related signals.The interconnection of these pathways was highlighted and summarized.Multiple signaling pathways work together to regulate endplate chondrocyte metabolism,which ultimately leads to the endplate degeneration.This review might shed light on early diagnosis and precise treatment of cartilage endplate degeneration.

关 键 词：力学刺激 软骨终板 软骨细胞 终板退变 信号通路 

分 类 号：R318.01[医药卫生—生物医学工程]