舒缓保湿修复霜联合激光治疗促进痤疮凹陷性瘢痕创面修复的临床效果  

Soothing moisturizing repair cream in promoting wound repair of acne depressed scar after laser operation: a clinical analysis

作　　者：秦绪艳 孙凤兰 于钰 韩进华 李生慧 郑玮清[1] Qin Xuyan;Sun Fenglan;Yu Yu;Han Jinhua;Li Shenghui;Zheng Weiqing(Department of Dermatology,Qingdao Hiser Hospital Affiliated to Qingdao University,Qingdao 266000,China;Innovation Department of Qingdao Youdo Bioengineering Co.,Ltd.,Qingdao 266000,China)

机构地区：[1]青岛大学附属青岛市海慈医院皮肤科,山东青岛266000 [2]青岛优度生物工程有限公司创新部,山东青岛266000

出　　处：《中华医学美学美容杂志》2021年第4期320-324,共5页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：青岛市2018年度医药科研指导计划(2018-WJZD039)。

摘　　要：目的探讨舒缓保湿修复霜对痤疮凹陷性瘢痕剥脱性点阵激光术后创面修复的效果和安全性。方法2018年10月至2020年6月,青岛大学附属青岛市海慈医院皮肤科以痤疮凹陷性瘢痕患者33例为研究对象,其中男8例、女25例,年龄20~36岁(29.6±8.6)岁。采用左右脸对照方法,激光术后试验侧予以舒缓保湿修复霜,对照侧予以安慰剂,通过采集患者激光术前、术后1 h、1、3、7、21 d面部图片、皮肤客观数据,结合研究者半主观评价、患者主观评价观察创面皮肤反应情况、创面愈合情况。结果激光术后1、3、7、21 d,试验侧皮肤含水量高于对照侧(P<0.05)、皮肤失水量低于对照侧(P<0.05);3、7、21 d,试验侧皮肤色素沉着指数低于对照侧(P<0.05);3、7 d,试验侧皮肤红斑指数低于对照侧(P<0.05);1、3、7 d,试验侧创面皮肤红斑、水肿、干燥紧绷等反应低于对照侧(P<0.05)。试验侧创面疼痛持续时间、结痂时间、脱痂时间、完全愈合时间短于对照侧(P<0.05)。患者对试验侧护理产品滋润度、舒适度满意度优于对照侧(P<0.05)。结论患者激光术后使用舒缓保湿修复霜无不良反应,可较好地抑制皮肤炎症反应、减少炎症后色素沉着、促进皮肤愈合,有助于激光术后创面修复。Objective To investigate the effectiveness and safety of soothing moisturizing repair cream on acne depressed scar exfoliative fractional laser wound repair.Methods From October 2018 to June 2020,the Department of Dermatology,Qingdao Haici Hospital Affiliated to Qingdao University took 33 patients with acne depressed scars as the research object,including 8 males and 25 females,aged from 20 to 36 years(29.6±8.6)years.The left and right face comparison method was adopted.After laser operation,the trial side was given a soothing moisturizing repair cream,and the control side was given a placebo.By collecting the patient's facial pictures and objective skin data before and after the laser operation,1 h,1 d,3 d,7 d,21 d,and combined with the researcher's semi-subjective evaluation and patient's subjective evaluation the wound skin reaction and wound healing were observed.Results At 1,3,7,21 days after laser operation,the skin water content of the test side was higher than that of the control side(P<0.05),and the skin water loss was lower than the control side(P<0.05);at 3,7,21 days,the skin pigment of the test side was lower than the control side(P<0.05);at 3,7 d,the test side skin erythema index was lower than the control side(P<0.05);at 1,3,7 d,the test side wound skin erythema,edema,dryness and tightness,etc.were better than the control side(P<0.05).The duration of pain,crusting time,scab removal time,and complete healing time of the wound on the test side were shorter than those on the control side(P<0.05).The patient's satisfaction with the moisturization and comfort of the nursing products on the trial side was better than that on the control side(P<0.05).Conclusions There is no adverse reaction to the soothing moisturizing repair cream after laser surgery,which can better inhibit skin inflammation,reduce post-inflammatory pigmentation,promote skin healing,and help repair the wound after laser surgery.

关 键 词：激光 舒缓保湿修复霜 剥脱性点阵激光 创面 修复作用 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]