木霉菌抗菌活肽peptaibols合成调控机制研究进展  

Research progress of the biosynthesis and regulation of the antibiotic peptaibols in Trichoderma

作　　者：张慧 周于聪[2] 梁言 张红艳 李雅乾 陈捷[1,3] ZHANG Hui;ZHOU Yu-Cong;LIANG Yan;ZHANG Hong-Yan;LI Ya-Qian;CHEN Jie(School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China;School of Life Science and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China;Key Laboratory of Urban(South)Agriculture,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai 200240,China;Shanghai Nongle Biological Products Co.,Ltd.,Shanghai 200240,China)

机构地区：[1]上海交通大学农业与生物学院,上海200240 [2]上海交通大学生命科学技术学院,上海200240 [3]上海交通大学农业部都市(南方)农业重点实验室,上海200240 [4]上海农乐生物制品股份有限公司,上海200240

出　　处：《菌物学报》2021年第8期1905-1917,共13页Mycosystema

基　　金：国家自然科学基金(31772211);上海交通大学2019年莙政创新实践项(2019-02-05);国家重点研发计划(2017YFD0200901)。

摘　　要：木霉菌Trichoderma spp.是广泛存在于土壤环境的丝状真菌,能够产生丰富的次生代谢物,具有抑制病原菌和促植物生长等功效,在农业和医药领域有广泛应用。Peptaibols是一类由非核糖体肽合成酶(non-ribosomal peptide synthetase,NRPS)合成的富含α-氨基异丁酸(Aib)的线性、具抗菌活性及长度不等的多肽。本文基于国内外关于木霉菌产生peptaibols的研究发展现状,重点介绍了peptaibols生物合成酶NRPSs基因簇,合成途径和调控模式,提出未来peptaibols类抗菌肽研究关注的焦点,有利于深入挖掘更具生物医药价值的抗菌肽产物。Trichoderma is a filamentous fungus genus widely existing in the soil environment.These fungi produce secondary metabolites such as peptaibols that have antimicrobial activities and plant growth promoters exteasively used as commercial biofungicides in agriculture and medicine.Peptaibols are a group of special antibacterial linear peptides rich in Aib synthesized by non-ribosomal peptide synthetases(NRPSs).Previous studies are mainly focused on diversity,structure,and mode of action of these peptide derivatives,but little emphasis has been paid to biosynthesis and regulation mechanism of these peptides.In this review,current understanding of the NRPS enzyme gene clusters,biosynthesis pathway and regulatory elements that involved in the synthesis and production of peptaibols is described.Areas that are focused in future,especially the way for mining the novel peptaibols with medicine value are also highlighted.

关 键 词：木霉菌 次级代谢产物 抗菌肽 非核糖体肽合酶 合成调控 

分 类 号：Q949.32[生物学—植物学]