检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:罗静 吴振龙 黄晓君[1,2] 张晓琦[1,2] 范春林[1,2] 叶文才[1,2] 王英[1,2] LUO Jing;WU Zhen-long;HUANG Xiao-jun;ZHANG Xiao-qi;FAN Chun-lin;YE Wen-cai;WANG Ying(Center for Bioactive Natural Molecules and Innovative Drugs Research,College of Pharmacy,Jinan University,Guangzhou 510632,China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New Drugs Research,Jinan University,Guangzhou 510632,China)
机构地区:[1]暨南大学药学院天然生物活性分子和创新药物研究中心,广东广州510632 [2]暨南大学广东省中药药效物质基础与创新药物研究重点实验室,广东广州510632
出 处:《中国中药杂志》2021年第13期3364-3367,共4页China Journal of Chinese Materia Medica
基 金:国家重点研发计划项目(2017YFC1703800);国家“重大新药创制”科技重大专项(2019ZX09735002-003)。
摘 要:蒜香藤原产南美洲的热带雨林地区,现在我国华南地区有引种,具多种药理活性,但目前对其化学成分的研究报道较少。该研究运用硅胶、十八烷基键合硅胶(ODS)、葡聚糖凝胶(Sephadex LH-20)、制备型高效液相色谱(PHPLC)等多种现代色谱技术,从蒜香藤枝叶95%乙醇提取物中分离得到2个化合物,并通过紫外光谱(UV)、红外光谱(IR)、高分辨质谱(HRESI-MS)和一维及二维核磁共振技术(NMR)等多种谱学方法,鉴定它们的结构分别为8,9-dimethoxy-α-lapachone(1)和7-hydroxy-8,9-dimethoxy-α-lapachone(2),为2个新的吡喃并萘醌类化合物,并分别命名为蒜香藤素甲(mansonin A,1)和蒜香藤素乙(mansonin B,2)。Mansoa alliacea,commonly known as garlic vine,is native to the tropical rain forests of South America and widely cultivated in South China.As a popular folk medicine with various biological activities,however,this plant remains to be fully elucidated in terms of its phytochemical constituents.In this study,two new pyranonaphthoquinones were isolated from the 95%ethanol extract of the leaves and twigs of M.alliacea by various chromatographic approaches including silica gel,octadecyl silica(ODS),Sephadex LH-20,and preparative high-performance liquid chromatography(PHPLC).Their structures were determined to be 8,9-dimethoxy-α-lapachone(1)and 7-hydroxy-8,9-dimethoxy-α-lapachone(2)by comprehensive spectroscopic analyses and therefore respectively named as mansonin A(1)and mansonin B(2).
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.200