加味杞菊地黄汤联合西药治疗子痫前期疗效及对患者外周血sFlt/PIGF和妊娠结局的影响  

Effect of modified Qiju Dihuang decoction combined with western medicine in preeclampsia and its influence on sFlt/PIGF in peripheral blood and pregnancy outcome

作　　者：谢宁[1] 李红岩 韩晓云[1] XIE Ning;LI Hongyan;HAN Xiaoyun(Department of Obstetrics,Affiliated Hospital of Jining Medical University,Jining 272001,China)

机构地区：[1]济宁医学院附属医院产科,山东济宁272001 [2]邹城市人民医院产科,山东邹城273500

出　　处：《陕西中医》2021年第9期1189-1192,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2019-0468)。

摘　　要：目的:探讨加味杞菊地黄汤联合西药治疗子痫前期疗效及对患者外周血可溶性Fms样酪氨酸激酶1(sFlt)/胎盘生长因子(PIGF)水平和妊娠结局的影响。方法:将90例子痫前期患者随机分为对照组(n=45)、观察组(n=45)。选择同期健康孕妇30例设为空白对照组。对照组采用硫酸镁联合硝苯地平缓释片治疗,观察组联合加味杞菊地黄汤治疗,比较三组血清sFlt/PIGF、中医证候积分、血压水平、妊娠结局、疗效及不良反应发生情况。结果:治疗后,观察组血清sFlt/PIGF、中医证候积分、收缩压(SBP)、舒张压(DBP)水平低于对照组(均P<0.05),观察组血sFlt/PIGF、中医证候积分高于空白对照组(均P<0.05)。三组不良妊娠结局发生率比较,差异无统计学意义(均P>0.05)。观察组总有效率高于对照组(P<0.05),两组用药期间恶心呕吐、腹泻便秘、心悸等不良反应发生率比较,差异无统计学意义(均P>0.05)。结论:加味杞菊地黄汤联合西药能降低子痫前期患者血清sFlt/PIGF、中医证候积分、血压水平,改善妊娠结局,提高临床疗效,安全性较高。Objective:To explore effect of modified Qiju Dihuang decoction combined with western medicine in patients with preeclampsia and influence on peripheral blood soluble Fms-like tyrosine kinase 1(sFlt)/placental growth factor(PIGF)levels and pregnancy outcome.Methods:90 patients with preeclampsia were randomly divided into control group(n=45)and observation group(n=45).30 healthy pregnant women during the same period were selected as the blank control group.The control group was treated with magnesium sulfate combined with nifedipine sustained-release tablets,and the observation group was treated with modified Qiju Dihuang decoction on the basis of the control group.The serum sFlt/PIGF,TCM syndrome score,blood pressure level,pregnancy outcome,curative effect and incidence of adverse reactions were compared among the three groups.Results:After treatment,serum sFlt/PIGF,TCM syndrome scores,SBP,and DBP in the observation group were significant lower than those in the control group(all P<0.05).The serum sFlt/PIGF and TCM syndrome scores of the observation group were significant higher than those in the blank control group(all P<0.05).The incidence of adverse pregnancy outcomes in the three groups were not statistically significant(all P>0.05).After treatment,the efficiency of the observation group was significant higher than the control group(P<0.05).There was no significant difference in adverse reactions of nausea and vomiting,diarrhea,constipation,and palpitations between the observation group and the control group(all P>0.05).Conclusion:Modified Qiju Dihuang decoction combined with western medicine can reduce serum sFlt/PIGF,TCM syndrome scores and blood pressure levels in patients with preeclampsia,and can improve pregnancy outcome,clinical efficacy,and better security.

关 键 词：子痫前期 加味杞菊地黄汤 硫酸镁 硝苯地平缓释片 血清sFlt/PIGF 妊娠结局 

分 类 号：R271.4[医药卫生—中医妇科学]