急性ST段抬高型心肌梗死患者血清LDH1、MYO水平与短期预后的相关性分析  

A Correlation Analysis of Serum LDH1 and MYO Levels and Short-Term Prognosis in Patients with Acute ST-Segment ElevationMyocardial Infarction

作　　者：刘少云[1] 魏荣荣 甘元梅 孙丽君 LIU Shaoyun;WEI Rongrong;GAN Yuanmei;SUN Lijun(Department of Cardiology,General Hospital of North China Petroleum Administration,Renqiu 062552,China)

机构地区：[1]华北石油管理局总医院心内科,河北任丘062552

出　　处：《标记免疫分析与临床》2021年第8期1283-1286,共4页Labeled Immunoassays and Clinical Medicine

基　　金：华北油田矿区医疗卫生临床调查相关研究(编号:2016-HB-G0401)。

摘　　要：目的探究急性ST段抬高心肌梗死(STEMI)患者入院时血清LDH1、肌红蛋白(MYO)水平,并分析血清LDH1、MYO与STEMI患者短期预后的关系。方法选取2019年3月至2020年3月本院收治的STEMI患者90例为研究对象(急性心肌梗死组),根据STEMI患者随访90天结果,分为预后良好组70例,和预后不良组20例;同期选择本院健康体检者90例为对照组。采用酶联免疫吸附(ELISA)法检测STEMI患者入院时和对照组体检时血清中LDH1水平,采用微粒子酶免疫分析法检测STEMI患者入院时和对照组体检时血清MYO水平;ROC曲线分析LDH1、MYO及二者联合检测对STEMI患者预后不良诊断价值。结果与对照组相比,急性心肌梗死组血清LDH1、MYO水平较高(P<0.05);与预后良好组相比,预后不良组血清LDH1、MYO水平较高(P<0.05);LDH1、MYO对STEMI患者不良预后诊断的AUC分别为0.870、0.825,二者联合对STEMI患者不同预后诊断的AUC为0.902,灵敏度为98.60%,特异性为75.00%。结论入院时血清LDH1、MYO水平升高与STEMI不良预后发生密切相关,对评估STEMI不良预后发生具有一定的应用价值。Objective To investigate the levels of serum LDH1 and myoglobin(myo)in patients with acute ST segment elevation myocardial infarction(STEMI),and to further analyze the relationship between serum LDH1,MYO and short-term prognosis of patients with STEMI.Methods A total of 90 patients with STEMI in our hospital from March,2019 to March,2020 were selected as the research objects(acute myocardial infarction group).According to the results of 90-day follow-up,the patients were divided into the good prognosis group(n=70)and poor prognosis group(n=20),while 90 healthy people in our hospital were selected as the control group.The level of serum LDH1 was detected by enzyme-linked immunosorbent assay(ELISA),while the level of serum MYO was detected by microparticle enzyme immunoassay on admission of patients with STEMI or physical examination for the control group.ROC curve was drawn to analyze the value of LDH1,MYO and their combined detection in the diagnosis of poor prognosis in patients with STEMI.Results Compared with those in the control group,the levels of serum LDH1 and MYO in the AMI group were higher(P<0.05).Compared with those in the good prognosis group,the levels of serum LDH1 and MYO in the poor prognosis group were higher(P<0.05).The AUCs of LDH1 and MYO in the diagnosis of poor prognosis in patients with STEMI were 0.870 and 0.825,respectively,while the AUC of the combined diagnosis was 0.902,with the sensitivity 98.60%,and the specificity 75.00%.Conclusion The increase of serum LDH1 and MYO levels at admission is closely related to the adverse prognosis of STEMI,which has certain application value in evaluating the adverse prognosis of STEMI.

关 键 词：ST段抬高型心肌梗死 乳酸脱氢酶同工酶1 肌红蛋白 短期预后 

分 类 号：R541.4[医药卫生—心血管疾病]