sdLDL-C、Hcy及D-二聚体在冠心病诊断中的价值  

The Value of sdLDL-C, Hcy and D-dimer in the Diagnosis of Coronary Heart Disease

作　　者：荣智慧 谢晓燕 RONG Zhihui;XIE Xiaoyan(Department of Laboratory Medicine,Ruici Hospital,Nantong University,Nantong Jiangsu 226000,China)

机构地区：[1]南通大学附属瑞慈医院检验科,江苏南通226000

出　　处：《中国继续医学教育》2021年第26期130-133,共4页China Continuing Medical Education

摘　　要：目的评价小而密低密度脂蛋白胆固醇、同型半胱氨酸和D-二聚体指标检测运用于冠心病患者临床诊断过程中的意义。方法文章将2019年1月—2020年5月本院诊断的100例冠心病患者用作试验组分析指标资料,并对试验组开展亚组区分,将单支病变患者、双支病变患者、三支病变患者分别区分为试验1组、试验2组、试验3组,同时选用同时间段内100个健康体检者作为对照组分析指标资料,关注对照组与试验组小而密低密度脂蛋白胆固醇检测数据结果、同型半胱氨酸检测数据结果、D-二聚体检测数据结果,分析试验组各亚组小而密低密度脂蛋白胆固醇检测数据结果、同型半胱氨酸检测数据结果、D-二聚体检测数据结果,统计血清sdLDL-C、Hcy、D-二聚体含量与CHD病变支数相关性。结果试验组小而密低密度脂蛋白胆固醇、同型半胱氨酸、D-二聚体检测数据结果明显高于对照组(P<0.05);试验2组、试验3组小而密低密度脂蛋白胆固醇、同型半胱氨酸、D-二聚体检测数据结果明显高于试验1组(P<0.05),试验3组小而密低密度脂蛋白胆固醇、同型半胱氨酸、D-二聚体检测数据结果明显高于试验2组(P<0.05);血清sdLDL-C、Hcy、D-二聚体含量与CHD病变支数均有正相关关系(P<0.05)。结论在冠心病患者诊断过程中选用小而密低密度脂蛋白胆固醇、同型半胱氨酸和D-二聚体指标检测有助于其临床诊断。Objective To evaluate the significance of the detection of small and dense low-density lipoprotein cholesterol,homocysteine and D-dimer in the clinical diagnosis of patients with coronary heart disease.Methods In this paper, 100 patients with coronary heart disease diagnosed in our hospital from January 2019 to May 2020 are used as analysis index data for the test group, and the test group is divided into subgroups. The patients with lesions were divided into test group 1, test group 2, and test group 3, and 100 healthy patients in the same period were selected as the control group analysis index data, focusing on the small and dense low density lipoprotein cholesterol in the control group and the test group Test data results, homocysteine test data results, D-dimer test data results, analysis of small and dense low-density lipoprotein cholesterol test data results of each subgroup of the test group, homocysteine test data results, D -Dimer test data results, statistical correlation between serum sdLDL-C, Hcy, D-dimer content and the number of CHD lesions. Results The test group's small and dense LDL cholesterol test data results, homocysteine test data results, and D-dimer test data results were improved compared with the control group (P<0.05);test group 2, test group 3 The results of small and dense low-density lipoprotein cholesterol test data, homocysteine test data and D-dimer test data were improved compared with the test 1 group (P<0.05), and the test 3 group was small and dense low density The results of lipoprotein cholesterol test data, homocysteine test data, and D-dimer test data were compared with those of the two groups (P<0.05);serum sdLDL-C, Hcy, D-dimer Content is positively correlated with the number of CHD lesions (P<0.05). Conclusion The use of small and dense low-density lipoprotein cholesterol, homocysteine and D-dimer in the diagnosis of coronary heart disease is helpful for its clinical diagnosis.

关 键 词：小而密低密度脂蛋白胆固醇 同型半胱氨酸 D-二聚体 冠心病 单支病变 双支病变 三支病变 

分 类 号：R446[医药卫生—诊断学]