Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: A review  

作　　者：Alicia Wang Kalpana Manthiram Fatma Dedeoglu Greg R.Licameli 

机构地区：[1]Department of Otolaryngology and Communication Enhancement,Boston Children’s Hospital,Boston,MA,USA [2]National Human Genome Research Institute,National Institutes of Health,Bethesda,MD,USA [3]Division of Immunology,Boston Children’s Hospital,Boston,MA,USA [4]Harvard Medical School,Boston,MA,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2021年第3期166-173,共8页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Periodic fever,aphthous stomatitis,pharyngitis,and adenitis(PFAPA)syndrome is the most common periodic fever condition in children,with most cases appearing by the age of 5.Although PFAPA is generally a self-limited condition,it can have a major impact on a child’s quality of life,as well as that of their family.Recent research has continued to shed light on the genetic and immunologic factors that play a role in the pathogenesis of PFAPA.There also exists significant heterogeneity in treatment strategies,and progress has been made to develop evidence-based management strategies and establish a standard of care.This review will outline current knowledge regarding the pathogenesis of PFAPA,as well as treatment strategies and our clinical experience.

关 键 词：PFAPA Periodic fever Recurrent fever 

分 类 号：R725[医药卫生—儿科] R781.5[医药卫生—临床医学] R766