亚胺培南用药现状及其与常见革兰氏阴性菌耐药性的相关性分析  被引量:6

Current situation of imipenem drug use and correlation analysis between drug resistance and common gram-negative bacteria

在线阅读下载全文

作  者:陈刚[1] 杨勇 罗安静 张港 冯佼 Chen Gang;Yang Yong;Luo Anjing;Zhang Gang;Feng Jiao(Department of Pharmacy,Sichuan Linshui County People's Hospital,Sichuan Guang'an 638500,China;Department of Pharmacy,Sichuan Academy Medical Sciences,Sichuan Province People's Hospital,Chengdu 610072,China;Department of Pharmacy,Affiliated Hospital of North Sichuan Medical College,Sichuan Nanchong 637000,China;Department of Laboratory Medicine,Linshui County People’s Hospital,Sichuan Guang'an 638500)

机构地区:[1]四川省邻水县人民医院药剂科,四川广安638500 [2]四川省医学科学院,四川省人民医院药学部,成都610072 [3]川北医学院附属医院药剂科,四川南充637000 [4]四川省邻水县人民医院检验科,四川广安638500

出  处:《新发传染病电子杂志》2021年第3期225-229,共5页Electronic Journal of Emerging Infectious Diseases

基  金:四川省科技创新苗子工程资助项目(2019056)。

摘  要:目的了解亚胺培南用药现状及其对常见革兰氏阴性菌的耐药性,为临床控制病原菌耐药提供参考。方法统计四川省邻水县人民医院2017-2018年亚胺培南平均每日每百张床位的用药强度,分析常见革兰氏阴性菌(铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌、阴沟肠杆菌、流感嗜血杆菌、鲍氏不动杆菌)耐药率和亚胺培南用药强度的相关性。结果2018年亚胺培南用药的限定日剂量(DDDs)、抗菌药物使用强度(AUD)较2017年明显增加,差异有统计学意义(P<0.05)。2017-2018年培养分离革兰氏阴性菌共1092株,其中2017年327株,2018年765株;铜绿假单胞菌感染主要分布于呼吸道、眼鼻口腔部位;肺炎克雷伯菌、阴沟肠杆菌、流感嗜血杆菌、鲍氏不动杆菌感染主要分布于呼吸道;大肠埃希菌于眼鼻口腔、泌尿道、血液和呼吸道均可分布。常见革兰氏阴性菌对亚胺培南耐药率为6.32%,其中肺炎克雷伯菌、大肠埃希菌、阴沟肠杆菌、流感嗜血杆菌对亚胺培南的耐药率较低,而铜绿假单胞菌、鲍氏不动杆菌对亚胺培南的耐药率较高。2018年铜绿假单胞菌对亚胺培南的耐药率较2017年明显增高,鲍氏不动杆菌对亚胺培南的耐药率较2017年明显降低(P<0.05)。亚胺培南DDDs、AUD与铜绿假单胞菌、肺炎克雷伯菌、流感嗜血杆菌耐药率呈明显的正相关(P<0.05),而与大肠埃希菌耐药率无明显相关性(P>0.05)。结论亚胺培南用药量与革兰氏阴性菌耐亚胺培南的发生率具有明显相关性,临床医师应重视合理使用亚胺培南,避免耐药菌出现。Objective To understand the current situation of imipenem drug use and correlation analysis between drug resistance and common gram-negative pathogenic bacteria,to provide reference for clinical control of pathogen resistance.Methods Statistics from Sichuan Linshui county People's Hospital during the period of 2017-2018 imipenem drug use intensity per hundred beds and day,correlation between imipenem drug use intensity and drug resistance of common gram-negative pathogenic bacteria(Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli,Enterobacter cloacae,Haemophilus influenzae,Acinetobacter baugh)were analyzed.Results DDDs and AUD of imipenem increased significantly in 2018 while compared with 2017,and the difference was significant(P<0.05).In 2017,327 gram-negative pathogenic bacteria were cultured and isolated.Seven hundred and sixty-five gram-negative pathogenic bacteria were cultured and isolated in 2018.One thousand and ninety-two gram-negative pathogenic bacteria were cultured and isolated in 2017-2018.Pseudomonas aeruginosa infection was mainly distributed in respiratory tract, eye-nose-mouth. Klebsiellapneumoniae, enterobacter cloacae, haemophilus influenzae and acinetobacter baugh were mainlydistributed in respiratory tract.Escherichia coli were mainly distributed in eye-nose-mouth, urinarytract, blood and respiratory tract.The drug resistance rate of gram-negative pathogenic bacteria toimipenem was 6.32%, among which pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli,enterobacter cloacae and haemophilus influenzae had lower drug resistance rate to imipenem, whileAcinetobacter baumannii had higher drug resistance rate to imipenem. The drug resistance rate ofpseudomonas aeruginosa to imipenem in 2018 was significantly higher than that in 2017, and the drugresistance rate of acinetobacter bauxis to imipenem was significantly lower than that in 2017, P<0.05. DDDs and AUD were positively correlated with pseudomonas aeruginosa, klebsiella pneumoniaeand haemophilus influenzae (P <0.05), w

关 键 词:革兰氏阴性菌 亚胺培南 耐药 细菌培养 药物敏感试验 

分 类 号:R446.5[医药卫生—诊断学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象