心包内心外膜脂肪百分比与2型糖尿病患者早期心功能相关性研究  

Correlation between the percentage of epicardial adipose tissue in the pericardium and early cardiac function changes in type 2 diabetic patients without heart failure

作　　者：荐志洁[1] 刘哲[1] 周丽 张惠[1] 丁宁宁 鱼博浪[1] 杨健[1] JIAN Zhijie;LIU Zhe;ZHOU Li;ZHANG Hui;DING Ningning;YU Bolang;YANG Jian(Department of Radiology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院医学影像科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2021年第5期725-729,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：中华国际医学交流基金会2019 SKY影像科研基金(No.Z-2014-07-1912)。

摘　　要：目的探讨心包内心外膜脂肪百分比与2型糖尿病患者早期心功能的相关性。方法回顾性收集2012-2014年西安交通大学第一附属医院影像科行CTA检查的住院2型糖尿病患者及同期的随机非糖尿病住院患者,记录其临床资料、实验室检查、心动超声、基于心脏CTA的心外膜脂肪(epicardial adipose tissue,EAT)体积及心包内心外膜脂肪百分比,比较两组间EAT定量指标与左心室功能、临床及生物学参数的差异,分析心功能参数与EAT参量的相关性。结果2型糖尿病患者左心室每搏输出量(stroke volume,SV)为(61.41±15.95)mL,低于对照组的(79.41±15.19)mL(P<0.05),且心包内EAT比例、血浆总胆固醇及低密度脂蛋白胆固醇均与其相关,相关系数分别为−0.501、−0.136、−0.377。其中心包内心外膜脂肪比例在控制其他因素的条件下,仍与SV呈中等线性负相关(r=−0.470,P<0.001)。结论心包内心外膜脂肪百分比与2型糖尿病患者早期左心室SV减低相关,提示其可作为量化2型糖尿病心功异常的敏感指标。Objective To explore the correlation between the percentage of epicardial adipose tissue(EAT)and cardiac function in type 2 diabetes mellitus without heart failure.Methods We recruited diabetic inpatients and random non-diabetic inpatients who underwent CTA examinations in the Imaging Department of The First Affiliated Hospital,Xi’an Jiaotong University,from 2012 to 2014 as the research subjects.Their clinical data,laboratory examinations,echocardiography,and EAT quantification based on cardiac CTA were analyzed retrospectively.The parameters were compared between the two groups.Then the correlation between cardiac function parameters and EAT parameters was analyzed.Results Compared with those in control group,type 2 diabetic patients without heart failure had lower left ventricular stroke volume(61.41±15.95 vs.79.41±15.19,P=0.047),and the percentage of EAT in the pericardium,plasma total cholesterol,and low-density lipoprotein cholesterol were all related to it.The correlation coefficients were−0.501,−0.136,and−0.377.The percentage of EAT in the pericardium still had a moderately linear negative correlation with SV when the other factors were under control(r=−0.470,P<0.001).Conclusion The percentage of EAT is asseated with early decreased left ventricular SV in patients with type 2 diabetes.It can be used as a sensitive index to quantify cardiac function abnormalities in type 2 diabetes.

关 键 词：2型糖尿病 心外膜脂肪 心功能 

分 类 号：R445[医药卫生—影像医学与核医学]