心肌能量底物代谢重构与心力衰竭关系的研究进展  

Research progress on the metabolic remodeling of myocardial energy substrate in heart failure

作　　者：高文静 马宏[1] 项美香[1] Gao Wen-Jing;Ma Hong;Xiang Mei-Xiang(Department of Cardiology,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院心血管内科,杭州310009

出　　处：《解放军医学杂志》2021年第8期822-826,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金面上项目(81870203)。

摘　　要：心力衰竭是各种心血管疾病的终末状态,并伴随出现一系列的能量代谢改变,包括能量底物的转变、线粒体功能障碍及高能磷酸化合物耗竭等。正常心脏以脂肪酸作为主要的能量代谢底物,心力衰竭时心肌脂肪酸代谢受损,发生以酮体利用增加为特点的代谢底物转换。认识心力衰竭过程中心肌底物的选择、调控机制及其病理生理意义,对发掘能量代谢治疗靶点具有重要的指导意义。该文就心力衰竭时心肌能量代谢底物的转变,尤其是近年来以酮体作为底物的最新研究进展进行综述。Heart failure is the end state of various cardiovascular diseases,accompanied by a series of energy metabolism changes including transformation of energy substrates,mitochondrial dysfunction,and depletion of high-energy phosphate compounds,etc.In normal heart,fatty acid is the main energy metabolism substrate.However,myocardial substrate metabolism is damaged during heart failure,and metabolic substrate conversion characterized by ketone body occurred.It is of great significance to better understand the metabolism substrate selection during heart failure,regulatory mechanism and its pathophysiological significance for developing novel therapeutics targeting heart failure.The research progress on the changes of myocardial energy metabolism substrates in heart failure,especially the latest progress of ketone body as the substrate in recent years were reviewed in present paper.

关 键 词：心力衰竭 代谢重构 底物 酮体 

分 类 号：R541.6[医药卫生—心血管疾病]