正电子断层显像技术在镶边空泡肌病中的应用研究进展  

Research progress of PET molecular imaging in rimmed vacuolar myopathy

作　　者：李珂[1] 石强[2] Li Ke;Shi Qiang(Department of Neurology,the Second Medical Center of PLA General Hospital,Beijing 100853,China;Department of Neurology,the First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第二医学中心神经内科,北京100853 [2]解放军总医院第一医学中心神经内科,北京100853

出　　处：《解放军医学杂志》2021年第8期827-830,共4页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金青年项目(81601086)。

摘　　要：镶边空泡肌病是具有特征性骨骼肌病理特点的一组疾病,其病理特点之一为β淀粉样蛋白(Aβ)及磷酸化tau蛋白在肌纤维中的异常沉积。近年来得益于分子影像技术的发展,正电子断层显像技术(PET)已被广泛应用于阿尔茨海默病的影像诊断,分子影像PET亦可以显示肌肉内沉积的异常蛋白,有助于镶边空泡肌病的早期诊断及鉴别诊断,为PET提供了新的应用方向。该文主要对PET在镶边空泡肌病中的应用进展进行综述,以期为临床工作的实施提供参考依据。Rimmed vacuole myopathy is a group of disease with characteristic myopathological features,which including deposition of abnormal proteins,such asβ-amyloid protein(Aβ)and phosphorylated tau proteins etc.In recent years,positron emission tomography(PET)has been widely used in the imaging diagnosis of Alzheimer’s disease(AD)due to the development of molecular imaging technology.Recently,some studies have indicated that molecular imaging PET can also show the abnormal deposition proteins in muscles,which is helpful for the early diagnosis and differential diagnosis of rimmed vacuolar myopathy,and provides a new application for PET.The application directions of PET in rimmed vacuolar myopathy were reviewed in this article,in order to provide a reference base for the implementation of clinical work.

关 键 词：镶边空泡肌病 正电子断层显像技术 Β淀粉样蛋白 TAU蛋白 

分 类 号：R445.6[医药卫生—影像医学与核医学]