超声引导经颈椎间孔臭氧注射治疗颈椎间盘突出症的效果及对血清免疫炎症因子水平的影响  

Effect of Ultrasonic-guided Ozone Injection through Cervical Foraminal in the Treatment of Cervical Disc Herniation and Its Influence on Serum Immune Inflammatory Factors Levels

作　　者：林水华 周凤 林苏华 LIN Shuihua;ZHOU Feng;LIN Suhua(Shaoguan Railway Hospital,Shaoguan 512023,China;不详)

机构地区：[1]韶关市铁路医院,广东韶关512023

出　　处：《中外医学研究》2021年第24期94-96,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：韶关市科技计划项目(2019sn039)。

摘　　要：目的:探讨超声引导经颈椎间孔臭氧注射治疗颈椎间盘突出症的效果及对血清免疫炎症因子水平的影响。方法:回顾性分析2019年6月-2020年6月本院接诊的60例颈椎间盘突出症患者临床资料,按照治疗方式不同分为观察组和对照组,各30例,两组均使用超声引导经颈椎间孔神经阻滞治疗,观察组使用臭氧注射,对照组使用地塞米松注射,总共治疗3次。比较两组治疗后1个月的临床疗效,治疗前、治疗后1个月视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、血清肿瘤坏死因子-α(TNF-α)、干扰素-γ(INF-γ)、白细胞介素-17(IL-17)水平及治疗期间不良反应发生率。结果:治疗后,观察组总有效率为93.33%,明显高于对照组的70.00%,差异有统计学意义(P<0.05);治疗后,观察组VAS评分、ODI评分分别为(2.88±0.40)、(10.06±2.54)分,均明显低于对照组的(3.76±0.32)、(15.82±2.60)分,差异有统计学意义(P<0.05);治疗后,观察组血清TNF-α、INF-γ、IL-17水平分别为(269.04±51.62)、(421.52±76.39)、(201.65±39.25)pg/ml,均明显低于对照组的(402.51±73.83)、(583.76±95.35)、(293.42±44.71)pg/ml,差异有统计学意义(P<0.05);两组治疗期间均无明显不良反应发生。结论:超声引导经颈椎间孔臭氧注射治疗颈椎间盘突出症的效果明显,且可有效改善血清免疫炎症因子水平,值得临床推广。Objective:To study the effect of ultrasonic-guided ozone injection through cervical foraminal in the treatment of cervical intervertebral disc herniation and its influence on serum immune inflammatory factors levels.Method:Clinical data of 60 patients with cervical disc herniation admitted to our hospital from June 2019 to June 2020 were retrospectively analyzed,according to different treatment methods,they were divided into observation group and control group,with 30 cases in each group,the ultrasound-guided through cervical foraminal nerve block was used in both groups,the observation group received ozone injection,and the control group received Dexamethasone injection,the total treatment was 3 times.The clinical efficacy 1 month after treatment,the visual analogue scale(VAS),Oswestry disability index(ODI),serum tumor necrosis factor-α(TNF-α),interferon-γ(INF-γ)and interleukin-17(IL-17)levels before and 1 month after treatment,and the incidence of adverse reactions during treatment of the two groups were compared.Result:After treatment,the total effective rate in observation group was 93.33%,which was significantly higher than 70.00%of control group,and the difference was statistically significant(P<0.05);after treatment,the VAS score and ODI score in the observation group were(2.88±0.40),(10.06±2.54)points,which were significantly lower than(3.76±0.32),(15.82±2.60)points in the control group,and the differences were statistically significant(P<0.05);after treatment,the serum TNF-α,INF-γand IL-17 levels in observation group were(269.04±51.62),(421.52±76.39),(201.65±39.25)pg/ml,which were significantly lower than(402.51±73.83),(583.76±95.35),(293.42±44.71)pg/ml in the control group,and the difference were statistically significant(P<0.05);there were no obvious adverse reactions in the two groups during treatment.Conclusion:The ultrasonic-guided ozone injection through cervical foraminal is effective in the treatment of cervical disc herniation,and which can effectively improve the serum immune in

关 键 词：颈椎间盘突出症 超声引导 臭氧 血清免疫炎症因子 疗效 不良反应 

分 类 号：R681.53[医药卫生—骨科学]