白介素1在炎症性关节痛中的表达及临床意义  

The expression and clinical significance of interleukin 1 in inflammatory joint pain

作　　者：王宁[1] 李洋 周居燕 梁燕[1] WANG Ning;LI Yang;ZHOU Juyan;LIANG Yan(Department of Laboratory Medicine,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院检验科,北京100020

出　　处：《中国疼痛医学杂志》2021年第7期516-520,共5页Chinese Journal of Pain Medicine

基　　金：国家自然科学基金(81901350)。

摘　　要：目的:探讨炎症性关节痛(inflammatory joint pain)病人血清中白介素1(interleukin 1)的表达水平及临床意义。方法:根据纳入和排除标准选取初次就诊我院的炎症性关节痛(C反应蛋白和红细胞沉降率均高于正常值范围)病人31例纳入试验组,同时选取初次就诊我院的年龄、性别等基本信息与试验组相匹配的非炎症性关节痛(C反应蛋白和红细胞沉降率均处于正常值范围)病人31例、机械压迫痛(椎管狭窄、椎间盘突出)病人31例及年龄、性别均匀分布的健康人80名为对照组,其中炎症性关节痛病人、非炎症性关节痛病人及机械压迫痛病人疼痛视觉模拟评分法(visual analogue scale,VAS)评分均≥4,健康人群评分均为0。使用ELISA试剂盒检测上述两组人群血清中白介素1α和白介素1β的含量。结果:非炎症性关节痛病人、机械压迫痛病人及正常人群血清中C反应蛋白(C-reactive protein)和红细胞沉降率(erythrocyte sedimentation rate)均在正常值范围内,白介素1α和白介素1β的含量处于较低水平;炎症性关节痛病人血清中C反应蛋白、红细胞沉降率及白介素1α和白介素1β的含量明显高于上述对照组。结论:血清中白介素1α和白介素1β可能是炎症性关节痛特异的生物标志物,可与病人体征、C反应蛋白以及红细胞沉降率等综合判断关节痛是否由炎症引起的,从而对炎症性关节痛进行及早诊断和治疗。Objective:To investigate the expression and clinical significance of interleukin-1 in the serum of patients with inflammatory joint pain.Methods:According to the inclusion and exclusion criteria,31 patients with inflammatory joint pain(serum C-reactive protein and erythrocyte sedimentation rate were higher than normal range)who visited our hospital for the first time were recruited in the experimental group.31 patients with non-inflammatory joint pain(serum C-reactive protein and erythrocyte sedimentation rate was in normal range)who matched basic information of the experimental group such as age and gender,31 patients with mechanical compression pain(spinal canal stenosis,intervertebral disc herniation)and 80 healthy people were recruited in the control group.Patients with inflammatory joint pain,non-inflammatory joint pain and mechanical compression pain were all≥4 using visual analogue scale,and the scores of healthy people were all 0.ELISA kits were used to detect the levels of interleukin-1αandβin the serum of the two groups of people.Results:Values of serum C-reactive protein and erythrocyte sedimentation rate in patients with non-inflammatory joint pain,mechanical compression pain and normal people were in the normal range,and the content of interleukin-1αandβwere at low level;The content of C-reactive protein,erythrocyte sedimentation rate,interleukin-1αandβin the serum of patients with inflammatory joint pain were significantly higher than control group.Conclusion:Serum interleukin-1αandβare possibly new biomarkers of inflammatory joint pain.Together with patient’s physical signs,C-reactive protein,erythrocyte sedimentation rate,interleukin-1αandβcan be used to diagnosis inflammatory joint pain.Thus,inflammatory joint pain can be diagnosed early and corresponding treatment can be carried out as soon as possible.

关 键 词：炎症性关节痛 血清 白介素1Α 白介素1Β 

分 类 号：R684.3[医药卫生—骨科学]