无创正压通气对慢阻肺合并肺动脉高压的疗效探究  

Effect of Noninvasive Positive Pressure Ventilation on Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Artery Hypertension

作　　者：吴燕玲 黄颂平[1] 许庆华[1] WU Yanling;HUANG Songping;XU Qinghua(Quanzhou First Hospital Affiliated to Fujian Medical University,Quanzhou 362000,China;不详)

机构地区：[1]福建医科大学附属泉州第一医院,福建泉州362000

出　　处：《中外医学研究》2021年第23期34-36,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2018年泉州市科技局科技计划项目(2018N074S);2017年福建省科技厅科技计划项目(2017J01228)。

摘　　要：目的:观察无创正压通气对慢阻肺合并肺动脉高压的治疗效果。方法:研究对象为2019年1月-2021年1月笔者所在医院收治的78例慢阻肺合并肺动脉高压患者,根据家庭呼吸支持方式的不同将其分为对照组(39例)和试验组(39例)。对照组实施常规低流量氧疗,试验组实施无创正压通气。比较两组肺通气功能、肺动脉压力、血气分析及生活质量。结果:治疗后试验组FVC、FEV_1、FEV_1/FVC均高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组mPAP明显低于对照组,差异有统计学意义(P<0.05)。治疗后,试验组PaCO_2明显低于对照组,PaO_2、pH明显高于对照组,差异有统计学意义(P<0.05)。治疗后,试验组生活质量评分明显高于对照组,差异有统计学意义(P<0.05)。结论:在慢阻肺合并肺动脉高压治疗中实行无创正压通气疗法具有良好的效果,不仅可改善患者肺动脉压,而且可改善患者肺功能和血气指标,建议推广。Objective:To observe the therapeutic effect of noninvasive positive pressure ventilation on chronic obstructive pulmonary disease complicated with pulmonary artery hypertension.Method:The subjects were 78 patients with chronic obstructive pulmonary disease complicated with pulmonary artery hypertension admitted in our hospital from January 2019 to January 2021.They were divided into the control group(39 cases)and the experimental group(39 cases)according to different family respiratory support methods.The control group received conventional low-flow oxygen therapy,and the experimental group received noninvasive positive pressure ventilation.Pulmonary ventilation function,pulmonary artery pressure,blood gas analysis and quality of life were compared between the two groups.Result:After treatment,FVC,FEV1 and FEV1/FVC in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,mPAP in the experimental group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).After treatment,PaCO2 in the experimental group was significantly lower than that in the control group,while PaO2 and pH in the experimental group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the quality of life score of the experimental group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion:Noninvasive positive pressure ventilation has a good effect in the treatment of chronic obstructive pulmonary disease complicated with pulmonary artery hypertension,which can not only improve the pulmonary artery pressure,but also improve the pulmonary function and blood gas index of patients,so it is recommended to promote.

关 键 词：慢阻肺 肺动脉高压 无创正压通气 肺动脉压力 

分 类 号：R563.9[医药卫生—呼吸系统] R544.1[医药卫生—内科学]