大连地区献血前HBsAg筛查效果的分析与评价  

Performance evaluation of HBsAg screening before blood donation in Dalian

作　　者：高慧卉[1] 邓雪莲[1] 王新梅[1] 孙鹏 刘笑春 郭笑寒 GAO Huihui;DENG Xuelian;WANGXinmei;SUN Peng;LIU Xiaochun;GUO Xiaohan(Dalian Blood Center,Dalian 116001,China)

机构地区：[1]大连市血液中心,辽宁大连116001

出　　处：《中国输血杂志》2021年第8期882-885,共4页Chinese Journal of Blood Transfusion

摘　　要：目的评价大连地区献血前HBsAg筛查的实施效果,为进一步提高HBsAg筛查效率、改进筛查策略提供数据支持。方法对HBsAg确认阳性标本进行HBsAg定性定量检测和初筛试剂复测。计算献血前HBsAg筛查效率,比较首次献血者与重复献血者的筛查效率。结果2017~2018年间,共完成199553人次的献血前筛查,首次献血者95321人(63.2%)、重复献血者55396人(36.8%)。HBsAg初筛不合格献血者有1015人(首次/重复:999/16),初筛合格但经实验室检测确证为HBsAg+标本有113份(首次/重复:108/5)。首次献血者HBsAg初筛效率为10.9‰,远高于重复献血者的0.3‰(P<0.05)。初筛复测阳性率为41.1%(39/95),其中中强阳标本占比达70%(27/39)。复测阴性、弱阳性、中阳性和强阳性标本对应的HBsAg浓度中位数和范围依次为0.41 IU/mL(<0.05~11.35 IU/mL)、6.71 IU/mL(2.49~23.15 IU/mL)、36.48 IU/mL(7.01~>130 IU/mL)和92.44 IU/mL(18.7~>130 IU/mL),分布呈现明显差异(P<0.05)。结论本中心初筛选用的HBsAg快检试剂能够达到预期的使用要求,仅对首次献血者进行HBsAg初筛可以实现更高的筛查效率。Objective To improve the efficiency and screening strategy by evaluating the performance of HBsAg screening before blood donation in Dafirmed HBsAg positive samples were detected qualitatively and quantitatively,and retested with HBsAg rapid testing kit predonational used parallelly.Efficiency of HBsAg screening before donation was calculated,and compared between first-time and repeated donors.Results The pre-donation HBsAg screening was conducted for 199553 cases,including 95321 firsttime donors(63.2%)and 55396 repeated donors(36.8%).1015 donors(first-time/repeated:999/16)were reactive in HBsAg rapid testing.113 samples(first-time/repeated:108/5),initially negative in HBsAg rapid testing,were confirmed HBsAg positive by laboratory testing.The efficiency of pre-donation HBsAg screening for first-time donors(10.9‰)was significantly higher than that of repeated donors(0.3‰)(P<0.05).The positive rate of retesting was 41.1%(39/95),among which 70%were classified as median or strong positive.Significant difference was observed among HBsAg values(IU/mL)[median(range)]of negative,weak positive,median positive and strong positive samples(P<0.05)which were 0.41(<0.05-11.35),6.71(2.49-23.15),36.48(7.01->130)and 92.44(18.7->130),respectively.Conclusion The HBsAg rapid testing kit used in Dalian Blood Center could meet requirements for blood donor screening before donation,while good efficiency of HBsAg pre-donation screening could be achieved only in first-time blood donors.

关 键 词：HBsAg快速检测 HBSAG定量 献血者筛查 效果评价 

分 类 号：R446.1[医药卫生—诊断学]