调节纤维蛋白溶解活性干预输血相关急性肺损伤的潜能探讨  

Potential of modulating fibrinolytic activity in intervention of transfusion-related acute lung injury

作　　者：余云红 蒋鹏 孙盼[1] 苏娜[1] 袁欣 林方昭[1] YU Yunhong;JIANG Peng;SUN Pan;SU Na;YUAN Xin;LIN Fangzhao(Institute of Blood Transfusion,Chinese Academy of Medical Science&Peking Union Medical College,Chengdu 610052,China;The Third people′s hospital of Chengdu)

机构地区：[1]中国医学科学院北京协和医学院输血研究所,四川成都610052 [2]成都市第三人民医院

出　　处：《中国输血杂志》2021年第8期922-925,共4页Chinese Journal of Blood Transfusion

基　　金：国家自然科学基金(31801192);中国医学科学院医学与健康科技创新工程(2016-12M-3-024)。

摘　　要：输血相急性肺损伤(TRALI)是急性肺损伤(ALI)的1个亚类,其临床表现、诊断、病理机制均符合ALI。纤维蛋白过度沉积在肺部是发生ALI病变的特点之一,逆转纤维蛋白形成对于干预ALI具有重要意义。而纤维蛋白溶解(纤溶)活性降低是导致肺部纤维蛋白过度沉积的重要原因之一,也是TRALI的1个重要病理特征。本文从调节纤溶活性干预ALI有效性为切入点探讨调节纤溶活性干预TRALI的潜能。Transfusion-related acute lung injury(TRALI),with clinical manifestation,diagnosis and pathological mechanism consistent with acute lung injury(ALI),belongs to a sub-category of ALI.Excessive deposition of fibrin in lung is one of the characteristic of ALI,and reversing fibrin formation is of great significance to intervene ALI.The decrease of fibrinolytic activity is one of the important causes of excessive deposition of fibrin in lung,and also the important pathological feature of TRALI.This article discusses the potential of modulating fibrinolytic activity to intervene TRALI from the perspective of regulating the effectiveness of fibrinolytic activity to intervene ALI.

关 键 词：输血相关急性肺损伤 急性肺损伤 纤维蛋白溶解活性 纤维蛋白沉积 干预 

分 类 号：R457.13[医药卫生—治疗学] R563.8[医药卫生—临床医学]