4℃冷藏保存血小板的储存损伤与应用研究进展  

Advances in applicaiton of platelets with cold storage at 4℃and its storage lesion

作　　者：李文娟 何芮 尹湧华[2] 刘忠[1,2] LI Wenjuan;HE Rui;YIN Yonghua;LIU Zhong(School of Public Health,Anhui Medical University,Hefei 230032,China;Institute of Blood Transfusion,Chinese Academy of Medical Sciences and Peking Union Medical College)

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]中国医学科学院北京协和医学院输血研究所

出　　处：《中国输血杂志》2021年第8期926-930,共5页Chinese Journal of Blood Transfusion

基　　金：中国医学科学院医学与健康科技创新工程(2020-I2MCoV19-006,2016-I2M-3-024);中国医学科学院中央级公益性科研院所基本科研业务费专项资金(2018PT32016);四川省国际科技创新合作/港澳台科技创新合作项目(2020YFH0024)。

摘　　要：血小板输注是临床预防出血和止血的重要治疗手段之一,但目前(22±2)℃震荡保存的血小板保质期短,易造成细菌污染,输入人体可能产生输血不良反应等。4℃保存血小板可以明显延长血小板的保存时间、降低细菌污染的风险且有更好的止血效果,但4℃冷藏的血小板保存过程中存在储存损伤,输入人体后容易被激活,降低体内有效存活率。本文就4℃冷藏保存血小板的储存损伤和应用研究进展作一综述。Platelet transfusion is one of the important therapeutic methods for clinical prevention of bleeding and hemostasis.At present,agitated storage at(22±2)℃used for platelets leads to risk of bacterial growth,which limits platelet shelf life and safety in transfusion.Cold storage at 4℃can significantly promote the abovementioned drawbacks and present a better hemostatic effect.Platelets storage lesion(PSL)due to the cold storage,however,may lead to platelet activation following transfusion,thus reducing the effective survival rate in vivo.This paper reviews the research advances in PSL and the application of platelets stored at 4℃.

关 键 词：冷藏保存 血小板 储存损伤 低温保护剂 血小板添加液 

分 类 号：R457.1[医药卫生—治疗学] R331.143[医药卫生—临床医学]