肠道菌群、胆汁酸及其交互作用对炎症性肠病的影响及临床应用进展  

The influence of bile acid,microbiota and their interaction on inflammatory bowel disease and the related progress in clinical application

作　　者：岑蒙莎 郑霞[1] 戴宁[1] 许梦雀 Cen Mengsha;Zheng Xia;Dai Ning;Xu Mengque(Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University Medical College,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院消化内科,杭州310016

出　　处：《中华炎性肠病杂志（中英文）》2021年第3期242-245,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：国家自然科学基金(81700456、81640687);浙江省医药卫生科技面上项目(2018KY104、2018KY112);浙江省自然科学公益基金(LQ18H030001)。

摘　　要：肠道菌群在机体营养物质吸收、代谢和免疫防御等方面起着关键作用,被认为是维持人类宿主健康的基石。肝脏中合成的胆汁酸进入肠道后不仅能促进脂溶性物质的吸收,直接或间接地影响肠道菌群的结构和功能,又可在肠道菌群的作用下转变成次级胆汁酸,并通过肠肝循环被重吸收回肝脏。肠道菌群和胆汁酸之间复杂的对话机制参与炎症性肠病(IBD)等肠道炎症的发生发展。本文就肠道菌群、胆汁酸及其交互作用对IBD的影响和治疗应用的进展进行综述。Intestinal microbiota plays key roles in nutrient absorption,metabolism and immune defense,and is regarded as the cornerstone of maintaining the health status of human host.After entering the intestine,the bile acids synthesized in the liver can not only promote the absorption of fat-soluble substances but also directly or indirectly affect the structure and function of intestinal microbiota.Intestinal microbiota can change primary bile acids into secondary bile acids,and help it to be reabsorbed back to the liver through the enterohepatic circulation.The complex mechanism of microbiota-bile acids crosstalk is involved in the development of intestinal inflammation including inflammatory bowel disease(IBD).This article reviews the influence of intestinal microbiota,bile acids and their interaction on the pathogenesis of IBD and the related progress of therapeutic application.

关 键 词：炎症性肠病 肠道菌群 胆汁酸 交互作用 

分 类 号：R574[医药卫生—消化系统]