黄病毒入侵中枢神经系统的分子机制研究进展  

Research progress on molecular mechanism of flavivirus invading central nervous system

作　　者：陈浩威 崔旻 CHEN Haowei;CUI Min(College of Veterinary Medicine,Huazhong Agricultural University/State Key Laboratory of Agricultural Microbiology,Wuhan 430070,China)

机构地区：[1]华中农业大学动物医学院/农业微生物学国家重点实验室,武汉430070

出　　处：《华中农业大学学报》2021年第4期85-93,共9页Journal of Huazhong Agricultural University

基　　金：国家自然科学基金面上项目(31872455);中央高校基本科研业务费专项(2662018PY016)。

摘　　要：临床上黄病毒可以引起中枢神经系统(central nervous system,CNS)疾病,易造成神经系统的后遗症。黄病毒可以通过血源性途径、特洛伊木马途径和神经轴突转运的方式跨越血脑屏障(blood brain barrier,BBB)。病毒穿越BBB进入CNS后,被病毒激活的内皮细胞、胶质细胞和神经细胞会释放大量的炎性因子和上调表达黏附分子,将白细胞募集到CNS,白细胞浸润携带更多病毒进入CNS。普遍认为胶质细胞和神经细胞产生的炎性因子是导致BBB通透性增大的主要诱因。本文对黄病毒破坏BBB入侵CNS的分子机制研究进展进行综述,以便更好地了解黄病毒的致病机制,更有效地防范黄病毒的蔓延。Clinically,flaviviruses can cause central nervous system(CNS)diseases and easily cause sequelae of the nervous system.Flaviviruses can enter the brain through blood-borne pathways,Trojan horse pathways,and axon transport,ultimately leading to CNS infection.When the virus enters the CNS through BBB,glial cells and nerve cells activated by the virus will release a large number of inflammatory mediators and up-regulate the expression of adhesion molecules,recruiting leukocytes to the CNS.Leukocyte infiltration can carry more viruses into the CNS and destroy the integrity of the BBB.It is generally believed that the inflammatory factors produced by glial cells and nerve cells are the main cause of increased BBB permeability.This review will focus on the research progresses of the BBB damage and the CNS invasion to better understand of pathogenesis and effectively prevent the spreading of flaviviruses.

关 键 词：黄病毒 血脑屏障 内皮细胞 血液途径 特洛伊木马途径 神经炎症 嗜神经性病毒 虫媒传播疾病 

分 类 号：S852.659.6[农业科学—基础兽医学]