尿液相关细胞因子在系统性红斑狼疮肾脏病情评估中的意义  

Clinical significance of urinary cytokines in the evaluation of kidney damage in systemic lupus erythematosus

作　　者：吴永卓[1] 曹文婷[1] 邓丹琪[1] WU Yong-zhuo;CAO Wen-ting;DENG Dan-qi(Department of Dermatology,The Second Affiliated Hospital of Kunming Medical University,Kunming,Yimnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院皮肤科,云南昆明650101

出　　处：《皮肤病与性病》2021年第4期469-471,共3页Dermatology and Venereology

基　　金：云南省医疗卫生单位内设研究机构科研项目(2017NS314);云南省应用基础研究昆医联合专项(2014FB050,2019FE001[-148])。

摘　　要：目的明确尿液细胞因子TNF-α、IL-6水平在系统性红斑狼疮(SLE)肾脏病情评估中的临床意义。方法选取2018年2月至2019年2月在昆明医科大学附属第二医院住院的SLE患者30例,同期纳入性别、年龄相匹配的非红斑狼疮者30例作为对照。采用酶联免疫吸附试验(ELISA)测定患者和对照组的尿TNF-α、IL-6表达水平,并收集SLE患者的相关临床数据及资料。评估尿TNF-α、IL-6水平与SLE肾脏病情的关系。结果相对于对照组,SLE患者尿中TNF-α、IL-6水平明显升高,其差异具有统计学意义;且SLE患者尿TNF-α、IL-6水平与尿微量蛋白尿肌酐比均呈正相关;SLE患者尿TNF-α、IL-6水平与SLEDAI评分均无相关性。结论检测尿TNF-α、IL-6水平在SLE患者的肾脏病情评估中有重要意义。Objective To investigate the clinical significance of urinary cytokines TNF-αand IL-6 levels in the evaluation of kidney damage in systemic lupus erythematosus(SLE).Methods The clinical data and urinary sample of 30 SLE patients and 30 healthy controls were collected in the Second Affiliated Hospital of Kunming Medical University from February 2018 to February 2019.The level of urinary TNF-αand IL-6 was detected using ELISA,and clinical data of SLE patients were collected,so as to evaluate the relationship between urine TNF-α,IL-6 levels and SLE kidney damage.Results Urinary TNF-αand IL-6 levels in SLE patients were significantly higher than those in the control group;Urinary TNF-α,IL-6 and urine microalbuminuria-creatinine ratio were positively correlated.There was no correlation between urinary TNF-αand IL-6 levels in SLE patients with SLEDAI score.Conclusion The detection of urinary TNF-αand IL-6 levels is of great significance in the evaluation of renal damage in SLE patients.

关 键 词：系统性红斑狼疮 尿TNF-α 尿IL-6 尿微量蛋白尿肌酐比 SLEDAI评分 

分 类 号：R446.62[医药卫生—诊断学] R563.243[医药卫生—临床医学]