依诺肝素钠与低分子肝素钠治疗重度子痫前期的疗效及对血清LPO、CysC和PIGF影响的对比研究  

Comparative Study of Efficacy of Enoxaparin Sodium and Low Molecular Weight Heparin Sodium in the Treatment of Severe Pre-Eclampsia and Their Effects on Serum LPO,CysC and PIGF

作　　者：许丽丽 王芳 文清 谢恺俐 XU Lili;WANG Fang;WEN Qing;XIE Kaili(Dept.of Obstetrics,Zhuzhou Central Hospital,Hunan Zhuzhou 412007,China)

机构地区：[1]株洲市中心医院产科,湖南株洲412007

出　　处：《中国医院用药评价与分析》2021年第8期925-928,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：2019年湖南省自然科学基金项目(No.2019JJ60089)。

摘　　要：目的:比较依诺肝素钠与低分子肝素钠治疗重度子痫前期的疗效及对血清脂质过氧化物(LPO)、胱抑素C(CysC)和胎盘生长因子(PIGF)的影响。方法:选取2017年1月至2021年1月在株洲市中心医院住院治疗的重度子痫前期患者118例作为研究对象,采用随机数字表法分为观察组和对照组,每组59例。观察组患者采用依诺肝素钠治疗,对照组患者采用低分子肝素钠治疗。观察两组患者的临床疗效、血压、凝血功能、LPO、CysC和PIGF水平以及妊娠结局。结果:观察组患者的总有效率为88.14%(52/59),明显高于对照组的72.88%(43/59),差异有统计学意义(P<0.05)。与对照组相比,观察组患者治疗后的收缩压、舒张压、纤维蛋白原、D-二聚体、LPO和CysC水平更低,凝血酶原时间、活化部分凝血酶时间更长,PIGF水平更高,妊娠时间更长,剖宫产、胎儿窘迫和产后出血的发生率更低,且上述差异均有统计学意义(P<0.05)。结论:与低分子肝素钠相比,依诺肝素钠治疗重度子痫前期的临床疗效更好,血压控制更佳,抗凝、改善肾功能作用更明显,不良妊娠结局的发生率更低。OBJECTIVE:To compare and analyze the efficacy of enoxaparin sodium and low molecular weight heparin sodium in the treatment of severe pre-eclampsia and the effects on serum lipid peroxides(LPO),cystatin C(CysC)and placental growth factor(PIGF).METHODS:Totally 118 patients with severe pre-eclampsia admitted into Zhuzhou Central Hospital from Jan.2017 to Jan.2021 were extracted to be divided into the observation group and the control group via the random number table,with 59 cases in each group.The observation group was treated with enoxaparin sodium,while the control group received low molecular weight heparin sodium.Clinical efficacy,blood pressure,coagulation function,LPO,CysC and PIGF and pregnancy outcomes of two groups were observed.RESULTS:The total effective rate of the observation group was 88.14%(52/59),significantly higher than that of the control group(72.88%,43/59),and the difference was statistically significant(P<0.05).Compared with the control group,the observation group had lower levels of systolic blood pressure,diastolic blood pressure,fibrinogen,D-dimer,LPO and CysC,longer time of prothrombin,activated partial thrombin,higher levels of PIGF,longer time of pregnancy,and lower incidence of cesarean section,fetal distress and postpartum hemorrhage after treatment,the differences were statistically significant(P<0.05).CONCLUSIONS:Enoxaparin sodium is more effective than low molecular weight heparin sodium in the treatment of severe preeclampsia,with better blood pressure control,more obvious anticoagulation and improvement of renal function,and lower incidence of adverse pregnancy outcomes.

关 键 词：依诺肝素钠 低分子肝素钠 重度子痫前期 

分 类 号：R973.2[医药卫生—药品]