结核分枝杆菌WhiB蛋白家族的研究进展  

A review on WhiB-like family proteins in Mycobacterium tuberculosis

作　　者：朱才良(综述) 郭法谋(审校) 孙红宾(审校) ZHU Cai-liang;GUO Fa-mou;SUN Hong-bin(Department of Biology,College of Food and Bioengineering,Zhengzhou University of Light Industry,Zhengzhou 450000,Henan Province,China)

机构地区：[1]郑州轻工业大学食品与生物工程学院生物系,河南郑州450000

出　　处：《微生物学免疫学进展》2021年第4期87-92,共6页Progress In Microbiology and Immunology

基　　金：河南省高等学校重点科研项目计划(19A416008);河南省自然科学基金(212300410415)。

摘　　要：结核分枝杆菌(Mycobacterium tuberculosis, Mtb)是引起结核病的主要病原体。WhiB蛋白家族有7个成员(WhiB1-WhiB7),它们是Mtb编码的氧化还原敏感的转录因子,分别参与Mtb细胞分裂、分泌系统调节、毒性、抗生素抗性等生命活动。现对近年来WhiB蛋白家族相关研究,重点就WhiB1的结构和WhiB1、WhiB3、WhiB4、WhiB7的功能,WhiB蛋白家族对Mtb生命活动和耐药性产生的影响作一概述,旨在加深对WhiB家族相关蛋白结构与功能的理解,为开发新型抗生素提供新思路。Mycobacterium tuberculosis(Mtb) is the main pathogen causing tuberculosis. WhiB1-WhiB7, a unique group of redox-sensitive transcription factors encoded by whiB-like genes of Mtb, are widely involved in cell division, secretion regulation, cell toxicity, and antibiotic resistance. This article reviews on recent researches of the structure of WhiB1, the functions of WhiB1, WhiB3, WhiB4, and WhiB7, and the impact of the WhiB-like family proteins on biological activities and drug resistance of Mtb, aiming to deeply understand of the correlation of structure and function of WhiB-like family related proteins and provide new ideas for the development of novel antibiotics.

关 键 词：WhiB蛋白 结核分枝杆菌 铁硫蛋白 转录调控 

分 类 号：Q78[生物学—分子生物学]