以皮肤结节为显著表现的先天性白血病一例并文献复习  

Congenital leukemia with multiple skin lesions: a case report and literature review

作　　者：刘香[1] 谭兴友[1] 鲁楠[1] 牛李莉[1] 田中华[1] LIU Xiang;TAN Xingyou;LU Nan;NIU Lili;TIAN Zhonghua(Department of Dermatology,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院附属医院皮肤科,山东济宁272029

出　　处：《中国麻风皮肤病杂志》2021年第11期713-715,共3页China Journal of Leprosy and Skin Diseases

摘　　要：报道1例出生时以皮肤结节为显著表现的先天性白血病并文献复习。患儿,女,出生时即全身弥漫性多发大小不等紫红色结节;外周血示白细胞284.24×109/L,原始细胞90%;皮肤病理示真皮及脂肪层弥漫性密集分布大量非典型细胞,表皮未受累,免疫组化染色CD68、CD43阳性;骨髓穿刺示白细胞数明显增高,以原始和幼稚单核细胞为主占86.5%,计数100个白细胞未见有核红细胞,血小板极少见;外周血肿瘤细胞免疫分型:异常细胞占93.04%;诊断为先天性白血病。给予支持治疗,出生后22天死亡。We report a case of congenital leukemia with striking features of multiple skin lesions and review relevant literature.The newborn girl presented with peculiar widespread purple nodules.Her white blood cells(WBC)count was 284.24×109/L,and a differential count revealed immature cell accounted for 90%.Biopsy specimen from chest skin nodule showed infiltration of a large number of dense,diffuse,atypical cells in the entire dermis and extended into subcutaneous fat.Immunohistochemical stains revealed positive for CD68 and CD43.Bone marrow aspiration showed that the marrow space was packed with leukemic blasts and immature monocytes,and blasts immature monocytes accounted for about 86.5%and normal hematopoietic precursors were markedly decreased.Immunotyping of peripheral blood tumor cells showed abnormal cells accounted for 93.04%.The infant died 22 days after birth.

关 键 词：先天性白血病 皮肤结节 皮肤白血病 

分 类 号：R733.7[医药卫生—肿瘤]