磁共振弹性成像评价软肝颗粒治疗乙肝肝纤维化的临床疗效观察  

Evaluate the clinical efficacy of Ruangan granules on Hepatitis B related fibrosis by MRE

作　　者：廖炯[1] 彭得倜 韩志毅[1] 盘中贤 蒲学佳 邢宇锋 周大桥 LIAO Jiong;PENG Deti;HAN Zhiyi;PAN Zhongxian;PU Xuejia;XING Yufeng;ZHOU Daqiao(Department of Radiology,Shenzhen Traditional Chinese Medicine Hospital,Guangdong 518033,China;Department of Hepatology,Shenzhen Traditional Chinese Medicine Hospital,Guangdong 518033,China)

机构地区：[1]深圳市中医院放射影像科,广东深圳518033 [2]深圳市中医肝病科,广东深圳518033

出　　处：《医药前沿》2021年第23期21-23,共3页Journal of Frontiers of Medicine

基　　金：广东省中医药局项目(20211326)。

摘　　要：目的:观察磁共振弹性成像诊断乙肝肝纤维化及评价软肝颗粒的临床疗效。方法:选取2019年6月—2020年6月深圳市中医院肝病科住院及门诊符合乙肝肝纤维化诊断的患者60例,随机分为治疗组和对照组,每组30例。分别给予软肝颗粒联合恩替卡韦片和恩替卡韦片治疗48周,两组治疗前后均行MRE及Fibro Scan检查,通过MRE及FibroScan检查结果评价MRE的诊断价值及软肝颗粒的临床疗效。结果:经过48周治疗后对照组失访1例,实际全程观察为29例。MRE在诊断乙肝肝纤维化方面的Cutoff值为1.514 m/s,特异性和敏感性均高于FibroScan,软肝颗粒可以显著提高乙肝肝纤维化的逆转率。结论:MRE是早期诊断乙肝肝纤维化的有效方法,软肝颗粒可以显著提高乙肝肝纤维化的逆转率,值得应用。Objective To study the diagnosis of Hepatitis B fibrosis by magnetic resonance elastography and evaluate the clinical efficacy of Ruangan Granules.Methods A total of 60 patients with Hepatitis B fibrosis were randomly divided into treatment group and control group,who were treated with Ruangan Granules combined with Enticavir Tablets and Enticavir Tablets for 48 weeks.MRE and Fibroscan tests were performed before and after treatment in both groups.The diagnostic value of MRE and the clinical efficacy of Ruangan Granules were evaluated by the results of MRE and Fibroscan.Results The diagnosis Cutoff value of MRE on hepatitis B fibrosis was 1.514 m/s,the specificity and sensitivity were higher than FibroScan,Ruangan Granules could significantly improve the reversal rate of hepatitis B fibrosis.Conclusion MRE is an effective method for early diagnosis of hepatitis B fibrosis,and Ruangan Granules can significantly improve the reversal rate of hepatitis B fibrosis,which is worthy of popularization and application.

关 键 词：磁共振弹性成像(MRE) 乙肝肝纤维化 软肝颗粒 FIBROSCAN 

分 类 号：R445.2[医药卫生—影像医学与核医学]