Dietary incorporation of jojoba extract eliminates oxidative damage in livers of rats fed fumonisin-contaminated diet  

作　　者：Mosaad A.Abdel-Wahhab Olivier Joubert Aziza A.El-Nekeety Hafiza A.Sharaf Ferial M.Abu-Salem Bertrand H.Rihn 

机构地区：[1]Food Toxicology and Contaminants Department,National Research Center,Dokki,Cairo 12311,Egypt [2]Faculty of Pharmacy,EA 3452 CITHEFOR,Lorraine University,54001 Nancy Cedex,France [3]Department of Pathology,National Research Center,Dokki,Cairo 12311,Egypt [4]Department of Food Science and Technology,National Research Center,Dokki,Cairo 12311,Egypt

出　　处：《Hepatoma Research》2016年第1期78-86,共9页肝癌研究（英文版）

基　　金：supported by the National Research Centre,Dokki,Cairo,Egypt(Project No.10070112).

摘　　要：Aim:This study aimed to determine the composition of ethanol extract of jojoba seeds,and to evaluate its hepatoprotective effects in rats fed fumonisin B1(FB1)-contaminated diet.Methods:Jojoba seeds were extracted in 95%ethanol,and the chemical composition was determined.Male rats were divided into six groups and treated for 8 weeks as follows:(1)Untreated control;(2)FB1-contaminated diet(80 mg/kg diet);(3)low dose(0.5 mg/kg b.w.)jojoba extract;(4)high dose(1.0 mg/kg b.w.)jojoba extract;(5)low dose jojoba extract plus FB1;and(6)high dose jojoba extract plus FB1.Blood and liver samples were collected for different biochemical analyses and histological examinations.Results:The results indicated that the ethanolic extract of jojoba is rich in protein,phenolic compounds,phytic acid,and considerable amounts of simmondsin.Animals fed FB1-contaminated diet showed severe biochemical and histological changes typical to those reported in literature.Treatment with jojoba seed extract alone at the two tested doses did not induce significant alterations in all parameters tested.Combined treatment of jojoba seed extract with FB1 eliminated hepatotoxicity induced by FB1,especially at low dose of jojoba seed extract.Conclusion:The authors concluded that jojoba seed extract can be incorporated in FB1-contaminated feed to eliminate FB1-induced hepatotoxicity.

关 键 词：Fumonisin B1 health hazards jojoba seed liver mycotoxins oxidative stress 

分 类 号：R28[医药卫生—中药学]