高血压等因素与主动脉重构的相关性研究  

Study on the correlation between hypertension and other influencing factors and aortic remodeling

作　　者：陈莹[1] 黄荣杰[2] CHEN Ying;HUANG Rong-jie(Cardiovascular Department,Tianjin Medical University General Hospital Airport Hospital,Tianjin 300308,China;Cardiovascular Department,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]天津医科大学总医院空港医院心血管内科,天津300308 [2]广西医科大学第一附属医院心血管内科,广西南宁530021

出　　处：《吉林医学》2021年第9期2210-2214,共5页Jilin Medical Journal

摘　　要：目的:调查研究高血压等因素与主动脉重构的相关性。方法:于2013年12月在柳州市柳江县,采取分层多阶段整群随机抽样≥35岁居民共507人,根据高血压诊断标准分为高血压组与正常血压组。测量主动脉瓣环、窦部、窦管交界部、升主动脉内径,统计分析血压、高血压病程、年龄、性别、吸烟、体质量指数(BMI)、生化指标等影响因素与主动脉内径的相关性。结果:①正常血压组与高血压组主动脉窦部内径分别为(30.93±4.58)mm、(32.19±4.75)mm,窦管交界部内径分别为(26.31±3.04)mm、(27.84±3.06)mm,升主动脉内径分别为(29.28±3.58)mm、(31.34±3.93)mm,高血压组明显增宽,差异有统计学意义(P<0.05)。②单因素相关分析发现:主动脉不同解剖部位内径与吸烟、年龄、舒张压水平呈正相关,与女性呈负相关。收缩压水平与主动脉窦管交界部、升主动脉内径呈正相关。舒张压的相关系数r值大于收缩压。多重逐步线性回归发现性别是主动脉不同部位内径的影响因素,舒张压是主动脉窦管交界部、升主动脉内径的影响因素。③按年龄分组比较,主动脉窦部、窦管交界部、升主动脉重构在55~74岁人群突出,75岁后无明显改变。按血压级别分组,高血压1级组较正常血压组的主动脉窦部、窦管交界部、升主动脉内径升高,差异有统计学意义(均P<0.05)。结论:吸烟、性别、高血压、年龄是主动脉不同部位内径增宽的影响因素,舒张压与主动脉内径的相关性大于收缩压。Objective To investigate the correlation between hypertension and other influencing factors and aortic remodeling.Method In December 2013,a cluster random sampling was conducted in liuzhou to measure the inner diameter of aortic valve ring,sinus,sino-tubular junction(STJ)and ascending aorta of 507 residents who were over 35 years old,the correlation between age,gender,smoking,Body mass index,blood pressure,biochemical indexes and aortic diameter was analyzed.Results①Compared with the normal blood pressure group,the diameter of aortic sinus[(30.93±4.58)vs(32.19±4.75)mm],STJ[(26.31±3.04)vs(27.84±3.06)mm],the ascending aorta[(29.28±3.58)vs(31.34±3.93)]mm was significantly widened in the hypertension group(all P<0.05).②Single factor correlation analysis showed that the inner diameter of different anatomical parts of the aorta was positively correlated with smoking,age and diastolic blood pressure(DBP),but negatively correlated with women.Systolic blood pressure(SBP)was positively correlated with STJ diameter and ascending aorta diameter.DBP was more correlated with aortic diameter than SBP.Multiple stepwise linear regression revealed that sex was the influencing factor of the inner diameter of different parts of the aorta,while DBP was the influencing factor of the inner diameter of STJ and ascending aorta.③According to age group comparison,the remodeling of aortic sinus,STJ,ascending aorta were prominent in the population aged 55~74 year-old,and there was no significant change after the age of 75.According to the classification of blood pressure,the internal diameters of the aortic sinus,STJ and ascending aorta in grade 1 hypertension group were higher than those in normal blood pressure group(all P<0.05).Conclusion Smoking,gender,and age hypertension were the influencing factors of aortic diameter enlargement in different parts,and the correlation between DBP and aortic diameter was greater than that of SBP.

关 键 词：主动脉内径 主动脉重构 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]