重组干扰素α-2b联合维生素D对毛细支气管炎患儿炎症、免疫、氧化应激指标的影响  

Effects of recombinant interferon α-2b combined with vitamin D on inflammatory, immune and oxidative stress indexes in children with bronchiolitis

作　　者：成妤姣 朱英莉 CHENG Yujiao;ZHU Yingli(Luochuan County Hospital,Yan'an 727400,China)

机构地区：[1]洛川县医院,陕西延安727400

出　　处：《临床医学研究与实践》2021年第26期94-96,共3页Clinical Research and Practice

摘　　要：目的探讨重组干扰素α-2b联合维生素D对毛细支气管炎患儿炎症、免疫、氧化应激指标的影响。方法选取2018年1月至2020年1月收治的90例毛细支气管炎患儿,以抽签法将其随机分为对照组和观察组,各45例。对照组采用常规治疗+维生素D治疗,观察组在对照组基础上联合重组干扰素α-2b治疗。比较两组的炎症、免疫、氧化应激指标。结果治疗后,观察组的白细胞介素-4(IL-4)、嗜酸性粒细胞阳离子蛋白(ECP)水平低于对照组,γ干扰素(IFN-γ)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的免疫球蛋白G(IgG)水平高于对照组,免疫球蛋白E(IgE)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的丙二醛(MDA)、晚期蛋白氧化产物(AOPP)水平低于对照组,超氧化物歧化酶(SOD)水平高于对照组,差异具有统计学意义(P<0.05)。结论重组干扰素α-2b联合维生素D治疗小儿毛细支气管炎的效果显著,可促进炎症、免疫及氧化应激指标的改善。Objective To investigate the effects of recombinant interferonα-2b combined with vitamin D on inflammatory,immune and oxidative stress indexes in children with bronchiolitis.Methods Ninety children with bronchiolitis admitted from January 2018 to January 2020 were selected and randomly divided into control group and observation group by lottery method,with 45 cases in each group.The control group was treated with routine treatment+vitamin D,and the observation group was combined with recombinant interferonα-2b on the basis of the control group.The inflammatory,immune and oxidative stress indexes were compared between the two groups.Results After treatment,the levels of interleukin-4(IL-4)and eosinophil cationic protein(ECP)in the observation group were lower than those in the control group,the level ofγ-Interferon(IFN-γ)was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the level of immunoglobulin G(IgG)in the observation group was higher than that in the control group,while the level of immunoglobulin E(IGE)was lower than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of malondialdehyde(MDA)and advanced oxidation protein products(AOPP)in the observation group were lower than those in the control group,the level of superoxide dismutase(SOD)was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Recombinant interferonα-2b combined with vitamin D in the treatment of children with bronchiolitis has a significant effect,which can promote the improvement of inflammatory,immune and oxidative stress indexes.

关 键 词：重组干扰素Α-2B 维生素D 毛细支气管炎 儿童 

分 类 号：R969[医药卫生—药理学]