血清TPO-Ab、NT-proBNP及CRP在甲亢性心脏病早期诊断中的临床价值  

Clinical value of serum TPO-Ab, NT-proBNP and CRP in the early diagnosis of hyperthyroid heart disease

作　　者：田永波[1] 孙敏[1] 金安林[1] 杨慧慧[1] TIAN Yongbo;SUN Min;JIN Anlin;YANG Huihui(Baoji Hospital of Traditional Chinese Medicine,Baoji 721000,China)

机构地区：[1]宝鸡市中医医院,陕西宝鸡721000

出　　处：《临床医学研究与实践》2021年第26期109-112,共4页Clinical Research and Practice

摘　　要：目的研究血清甲状腺过氧化物酶抗体(TPO-Ab)、N端脑钠肽前体(NT-proBNP)及C反应蛋白(CRP)在甲亢性心脏病(HHD)早期诊断中的临床价值。方法纳入我院收治的甲亢患者175例,根据是否合并HHD将其分为单纯甲亢组(95例)和HHD组(80例),选择同期80例健康体检者作为对照组。比较三组TPO-Ab、NT-proBNP及CRP水平。分析TPO-Ab、NT-proBNP及CRP与HHD患者心功能分级的相关性。使用ROC曲线分析TPO-Ab、NT-proBNP及CRP对HHD的诊断价值。结果HHD组的TPO-Ab、NT-proBNP及CRP水平明显高于对照组和单纯甲亢组,差异具有统计学意义(P<0.05)。NYHA分级Ⅳ级患者的NT-proBNP和CRP水平明显高于Ⅰ、Ⅱ和Ⅲ级,差异具有统计学意义(P<0.05)。NT-proBNP和CRP与HHD患者心功能分级呈明显正相关(P<0.05)。NT-proBNP诊断HHD的AUC明显高于TPO-Ab和CRP(P<0.05)。结论与TPO-Ab和CRP相比,NT-proBNP对HHD诊断价值最高,并与HHD患者的心功能分级具有明显的相关性,可作为HHD早期诊断的有效指标。Objective To study the clinical value of serum thyroid peroxidase antibody(TPO-AB),N-terminal pro-brain natriuretic peptide(NT-probNP)and C-reactive protein(CRP)in the early diagnosis of hyperthyroid heart disease(HHD).Methods A total of 175 hyperthyroidism patients admitted in our hospital were divided into simple hyperthyroidism group(95 cases)and HHD group(80 cases)according to the combination of HHD or not,and 80 healthy patients during the same period were selected as control group.The levels of TPO-Ab,NT-proBNP and CRP in the three groups were compared.The correlation between TPO-Ab,NT-proBNP and CRP and cardiac function classification of HHD patients was analyzed.The ROC curve was used to analyze the diagnostic value of TPO-Ab,NT-proBNP and CRP for HHD.Results The levels of TPO-Ab,NT-proBNP and CRP in the HHD group were significantly higher than those in the control group and the simple hyperthyroidism group,and the differences were statistically significant(P<0.05).The levels of NT-proBNP and CRP in patients with NYHA gradeⅣwere significantly higher than those in gradeⅠ,ⅡandⅢ,and the differences were statistically significant(P<0.05).NT-proBNP and CRP were significantly positively correlated with cardiac function classification of HHD patients(P<0.05).The AUC of NT-proBNP in the diagnosis of HHD was significantly higher than that of TPO-Ab and CRP(P<0.05).Conclusion Compared with TPO-Ab and CRP,NT-proBNP has the highest diagnostic value for HHD,and obvious correlation with cardiac function classification of HHD patients,which can be used as an effective indicator for early diagnosis of HHD.

关 键 词：甲亢性心脏病 甲状腺过氧化物酶抗体 N端脑钠肽前体 C反应蛋白 

分 类 号：R563[医药卫生—呼吸系统]