Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations  

作　　者：Tiande Zou Jin Yang Xiaobo Guo Qin He Zirui Wang Jinming You 

机构地区：[1]Jiangxi Province Key Laboratory of Animal Nutrition,College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,Jiangxi,China [2]Jiangxi Province Key Innovation Center for Industry-Education Integration of High-Quality and Safety Livestock Production,Nanchang 330045,China

出　　处：《Journal of Animal Science and Biotechnology》2021年第3期1184-1195,共12页畜牧与生物技术杂志（英文版）

基　　金：This study was supported by the Pig Modern Industrial Technology System Grant of Jiangxi Province(JXARS-03).

摘　　要：Background:Seaweed-derived polysaccharides(SDP)represent an attractive source of prebiotic nutraceuticals for the food and animal husbandry industry.However,the mechanism by which SDP from Enteromorpha mediates pig growth are not fully understood.This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.Results:In Exp.1,240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200,400 or 800 mg/kg SDP,respectively,in a 21-day trial.Pigs on the 400 or 800 mg/kg SDP-supplemented group had greater ADG and lower F/G ratio than those on the control group(P<0.05).In Exp.2,20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet(CON group)or a basal diet supplemented with 400 mg/kg SDP(the optimum does from Exp.1),in a 21-day trial.Pigs fed the SDP diet had greater ADG,the concentrations of serum IL-6 and TNF-αand the activities of glutathione peroxidase,superoxide dismutase and catalase(P<0.05),and lower F/G,diarrhea rate,as well as serum D-lactate concentrations and diamine oxidase activity(P<0.05).Moreover,dietary SDP supplementation enhanced secretory immunoglobulin A content,villus height and villous height:crypt depth ratio in small intestine,as well as the lactase and maltase activities in jejunum mucosa(P<0.05).SDP supplementation elevated the mRNA levels of inflammatory responserelated genes(IL-6,TNF-α,TLR4,TLR6 and MyD88),and the mRNA and protein levels of ZO-1,claudin-1 and occludin in jejunum mucosa(P<0.05).Importantly,SDP not only increased the Lactobacillus population but also reduced the Escherichia coli population in cecum(P<0.05).Furthermore,SDP increased acetic acid and butyric acid concentrations in cecum(P<0.05).Conclusions:These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions,but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs.

关 键 词：Intestinal health MICROFLORA Pigs Seaweed-derived polysaccharides 

分 类 号：S828.5[农业科学—畜牧学]