基于整合药理学平台预测前列腺1号方治疗慢性前列腺炎作用机制  

Prediction of the mechanism of prostate prescription Ⅰ in the treatment of chronic prostatitis based on integrative pharmacology of traditional Chinese medicine

作　　者：张天宇 刘嘉 杨凯 曾明月[4] 董盼攀 曾庆琪 ZHANG Tian‐yu;LIU Jia;YANG Kai;ZENG Ming‐yue;DONG Pan‐pan;ZENG Qing‐qi(Nanjing University of Traditional Chinese Medicine,Nanjing 210023,China;Jiangsu Health Vocational College,Nanjing 210029,China;Zhangjiagang Hospital of Traditional Chinese Medicine,Zhangjiagang 215600,China;Beijing University of Traditional Chinese Medicine,Beijing 100029,China;Tongde Hospital of Zhejiang Province,Hangzhou 310012,China)

机构地区：[1]南京中医药大学,江苏南京210023 [2]江苏卫生健康职业学院,江苏南京210029 [3]张家港市中医医院,江苏张家港215600 [4]北京中医药大学,北京100029 [5]浙江省立同德医院,浙江杭州310012

出　　处：《海南医学院学报》2021年第17期1312-1318,共7页Journal of Hainan Medical University

基　　金：江苏省自然科学基金(BK20191498);江苏卫生健康职业学院校级课题重大项目(JKA201903)。

摘　　要：目的:应用中医药整合药理学方法预测前列腺1号治疗慢性前列腺炎(chronic prostatitis,CP)的潜在作用机制。方法:借助TCMIP平台中药材数据库,筛选出前列腺1号方有效化学成分;应用中药(含方剂)靶标预测功能,建立前列腺1号方的潜在靶标数据库。基于Human Phenotype Ontology数据库和蛋白质相互作用网络(PPI)数据库,明确CP疾病靶标并构建靶标相互作用网络;通过对前列腺1号治疗CP的候选靶标进行GO功能分析、KEGG通路富集分析,结合中外文献研究预测其治疗CP可能的生物途径和作用通路。结果:前列腺1号方通过8味中药、79个有效化学成分、33个核心靶标、11条通路发挥治疗慢性前列腺炎的药理作用。结论:前列腺1号对CP的干预治疗可能体现在抗炎抗肿瘤、细胞代谢、免疫调节、神经调节等方面。Objective:To investigate the potential mechanism of prostate prescription Ⅰ in the treatment of chronic prostatitis(CP)based on integrated pharmacology.Methods:The effective compounds of prostate prescriptionⅠwere screened by using TCMIP,and the potential target database of prostate prescription Ⅰ was established by using the target prediction function of TCMIP.Based on the Human Phenotype Ontology database and protein interaction network(PPI)database,the disease target of CP was identified and the target interaction network was constructed.Through the GO function analysis and KEGG pathway enrichment analysis of the candidate targets,Chinese and foreign literature studies were combined to predict the potential signaling pathway of prostate prescription Ⅰ in the treatment of CP.Results:A total of 79 effective compounds of prostate prescription Ⅰ exerted their effect on 33 targets through 11 pathways.Conclusions:Clinical efficacy of prostate prescription Ⅰ on CP may be reflected in anti‐inflammation and anti‐tumor,cell metabolism,immune regulation and neuroregulation and so on.

关 键 词：前列腺1号方 中医药整合药理学研究平台 慢性前列腺炎 潜在作用机制 

分 类 号：R285.5[医药卫生—中药学]