Conundrum of vitamin D on glucose and fuel homeostasis  

作　　者：Maria Mercedes Chang Villacreses Rudruidee Karnchanasorn Panadeekarn Panjawatanan Horng-Yih Ou Ken C Chiu 

机构地区：[1]Department of Clinical Diabetes,Endocrinology,and Metabolism,City of Hope National Medical Center,Duarte,CA 91010,United States [2]Division of Endocrinology,Metabolism and Nutrition,Department of Internal Medicine,Harbor-UCLA Medical Center,Torrance,CA 90509,United States [3]Division of Endocrinology,Department of Medicine,University of Kansas Medical Center,Kansas City,KS 66160,United States [4]Department of Internal Medicine,Bassett Medical Center,Cooperstown,NY 13326,United States [5]Department of Internal Medicine,National Cheng Kung University Hospital,National Cheng Kung University,Tainan 700,Taiwan

出　　处：《World Journal of Diabetes》2021年第9期1363-1385,共23页世界糖尿病杂志（英文版）（电子版）

摘　　要：As an endocrine hormone,vitamin D plays an important role in bone health and calcium homeostasis.Over the past two decades,the non-calcemic effects of vitamin D were extensively examined.Although the effect of vitamin D on beta cell function were known for some time,the effect of vitamin D on glucose and fuel homeostasis has attracted new interest among researchers.Yet,to date,studies remain inconclusive and controversial,in part,due to a lack of understanding of the threshold effects of vitamin D.In this review,a critical examination of interventional trials of vitamin D in prevention of diabetes is provided.Like use of vitamin D for bone loss,the benefits of vitamin D supplementation in diabetes prevention were observed in vitamin D-deficient subjects with serum 25-hydroxyvitamin D<50 nmol/L(20 ng/mL).The beneficial effect from vitamin D supplementation was not apparent in subjects with serum 25-hydroxyvitamin D>75 nmol/L(30 ng/mL).Furthermore,no benefit was noted in subjects that achieved serum 25-hydroxyvitamin D>100 nmol/L(40 ng/mL).Further studies are required to confirm these observations.

关 键 词：Vitamin D Glucose metabolism Diabetes mellitus Insulin sensitivity BETA 

分 类 号：R587.1[医药卫生—内分泌]