莫西沙星超短程治疗初治103例菌阳肺结核的临床效果  

Clinical efficacy of ultra-short course moxifloxacin in the treatment of 103 cases of bacteriological positive pulmonary tuberculosis

作　　者：黄玲[1] 刘国辉[1] HUANG Ling;LIU Guohui(Department of Pulmonary,the Third People’s Hospital of Shenzhen,Shenzhen 518000,China)

机构地区：[1]深圳市第三人民医院肺科,深圳518000

出　　处：《上海医药》2021年第17期22-23,29,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨对初治菌阳肺结核患者应用莫西沙星超短程治疗的临床效果。方法:选取206例初治菌阳肺结核患者,用随机数字表法分为对照组(n=103)和观察组(n=103)。对照组给予常规治疗,观察组在此基础上联合莫西沙星超短程治疗。对比两组病灶吸收有效率和不良反应发生情况;对比治疗2个月和疗程结束时两组痰结核菌转阴率。结果:治疗后观察组病灶吸收有效率显著优于对照组(98.0%vs 86.4%);治疗2个月和疗程结束时痰结核菌转阴率均优于对照组;不良反应发生率显著低于对照组(3.9%vs 13.6%)(均P<0.05)。结论:莫西沙星超短程治疗能有效提高初治菌阳肺结核患者病灶吸收有效率和痰结核菌转阴率,不良反应少,疗效显著。Objective:To investigate the clinical effect of ultra-short course moxifloxacin in the treatment of patients with newly diagnosed bacteriological positive pulmonary tuberculosis.Methods:Two hundred and six patients with bacteriological positive pulmonary tuberculosis were randomly divided into a control group(n=103)and an observation group(n=103).The control group was treated with routine therapy,and the observation group was additionally given ultra-short course moxifloxacin on this basis.The absorption rate and adverse reactions were compared between the two groups.The negative rates of sputum tuberculosis at 2 months after treatment and the end of treatment were also compared between the two groups.Results:After treatment,the effective rates of lesion absorption were significantly higher in the observation group than the control group(98.0%vs 86.4%).The negative rates of sputum tuberculosis were better and the incidence of adverse reactions was significantly lower in the observation group than the control group(all P<0.05).Conclusion:Ultra-short course moxifloxacin treatment can effectively improve the absorption rates of the lesion and the negative rates of sputum tuberculosis with less adverse reactions and significant efficacy.

关 键 词：莫西沙星 超短程治疗 菌阳肺结核 临床效果 

分 类 号：R978.19[医药卫生—药品] R521[医药卫生—药学]