槐杞黄颗粒辅助治疗儿童支气管哮喘疗效的真实世界研究  

Efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children:a real-world study

作　　者：王慧敏 刘传合[1] 刘长山[2] 王莹[3] 韩志英[4] 孙新 陈星[6] 安淑华[7] 多力坤·木扎帕尔[8] 芦爱萍 王敏[10] 程燕[11] 尹小梅 刘瀚旻[13] 王红[14] 华山 董丽[16] 黄英[17] 姜毅[18] 熊建新 丁圣刚[20] 赵顺英[21] 王金荣[6] 黄贵民 牟京辉[1] 陈育智[1] WANG Hui-Min;LIU Chuan-He;LIU Chang-Shan;WANG Ying;HAN Zhi-Ying;SUN Xin;CHEN Xing;AN Shu-Hua;DUOLIKUN Muzhapaer;LU Ai-Ping;WANG Min;CHENG Yan;YIN Xiao-Mei;LIU Han-Min;WANG Hong;HUA Shan;DONG Li;HUANG Ying;JIANG Yi;XIONG Jian-Xin;DING Sheng-Gang;ZHAO Shun-Ying;WANG Jin-Rong;HUANG Gui-Min;MU Jing-Hui;CHEN Yu-Zhi(Children's Hospital of Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]首都儿科研究所附属儿童医院,北京100020 [2]天津医科大学第二医院,天津300211 [3]华中科技大学同济医学院附属武汉儿童医院,湖北武汉430015 [4]山西省儿童医院,山西太原300013 [5]第四军医大学第一附属医院,陕西西安710000 [6]山东省立医院,山东济南250000 [7]河北省儿童医院,河北石家庄050031 [8]新疆医科大学第一附属医院,新疆乌鲁木齐830001 [9]广东省深圳远东妇儿科医院,广东深圳518001 [10]湖北省宜昌市中心人民医院,湖北宜昌443000 [11]天津中医药大学第二附属医院,天津300143 [12]北京清华长庚医院,北京102200 [13]四川大学华西第二医院,四川成都610000 [14]北京民航总医院,北京100020 [15]安徽省儿童医院,安徽合肥230022 [16]解放军总医院第七医学中心附属八一儿童医院,北京100010 [17]重庆医科大学附属儿童医院,重庆400014 [18]武汉大学人民医院,湖北武汉430060 [19]江苏省常州市儿童医院,江苏常州213000 [20]安徽医科大学第一附属医院,安徽合肥230022 [21]首都医科大学附属北京儿童医院,北京100045

出　　处：《中国当代儿科杂志》2021年第9期877-881,共5页Chinese Journal of Contemporary Pediatrics

摘　　要：目的观察槐杞黄颗粒辅助治疗儿童支气管哮喘的疗效。方法采取多中心、前瞻性、登记注册的真实世界研究方法,于全国21家医院门诊依序纳入已明确诊断支气管哮喘、年龄2~5岁、采用以下两种治疗方案之一的患儿:使用哮喘长期控制药物,即吸入激素和/或白三烯受体拮抗剂,但未使用槐杞黄颗粒(控制治疗组,n=390);使用哮喘长期控制药物,同时加用槐杞黄颗粒(联合治疗组,n=1014)。收集所有患儿的个人及临床资料,于治疗后第4、8、12、20、28、36周进行门诊或电话随访。随访内容包括哮喘发作情况、鼻炎症状等,并对随访观察指标的变化进行统计学分析。结果入组前两组患儿哮喘发作次数、天数及鼻炎发作天数比较差异均无统计学意义(P>0.05)。经治疗后,联合治疗组患儿每月哮喘发作天数、重度哮喘发作次数及鼻炎发作天数均显著少于控制治疗组(P<0.05)。两组患儿不良反应发生率比较差异无统计学意义(P=0.667)。结论在使用哮喘长期控制药物治疗基础上加用槐杞黄颗粒能够改善支气管哮喘患儿的临床症状及伴发的鼻炎症状,提高哮喘控制水平,且在治疗过程中使用安全,无明显不良反应。Objective To study the efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children.Methods A multicenter,prospective,and registered real-world study was performed for the children,aged 2-5 years,who had a confirmed diagnosis of bronchial asthma in the outpatient service of 21 hospitals in China.Among these children,the children treated with medications for long-term asthma control(inhaled corticosteroid and/or leukotriene receptor antagonist)without Huaiqihuang granules were enrolled as the control treatment group,and those treated with medications for long-term asthma control combined with Huaiqihuang granules were enrolled as the combined treatment group.The medical data of all children were collected.Outpatient or telephone follow-up was performed at weeks 4,8,12,20,28,and 36 after treatment,including asthma attacks and rhinitis symptoms.A statistical analysis was performed for the changes in these indices.Results There was no significant difference in the frequency of asthma attacks or rhinitis attacks between the two groups before treatment(P>0.05).After treatment,the combined treatment group had significantly lower frequencies of asthma attacks,severe asthma attacks,and rhinitis attacks compared with the control treatment group(P<0.05).There was no signification difference in the incidence rate of adverse reactions between the two groups(P=0.667).Conclusions Huaiqihuang granules in addition to medications for long-term asthma control can alleviate the symptoms of bronchial asthma and rhinitis and improve the level of asthma control in children with bronchial asthma,with good safety and little adverse effect.

关 键 词：支气管哮喘 槐杞黄颗粒 辅助治疗 儿童 

分 类 号：R725.6[医药卫生—儿科]