结核分枝杆菌脂阿拉伯甘露聚糖的免疫调节作用和诊断价值  

Immunomodulatory effect of Mycobacterium tuberculosis lipoarabinomannan and its value on tuberculosis diagnosis

作　　者：范雨鑫 刘玫肖 陈晶晶 徐鑫 张宇[1] 岳鹏 曹文静 宝福凯[1] 柳爱华[2] FAN Yu-xin;LIU Mei-xiao;CHEN Jing-jing;XU Xin;ZHANG Yu;YUE Peng;CAO Wen-jing;BAO Fu-kai;LIU Ai-hua(Key Laboratory for Tropical Infectious Diseases in Yunnan Provincial Universities,Department of Microbiology and Immunology,Kunming Medical University,Kunming 650500,China)

机构地区：[1]云南省高校热带传染病重点实验室昆明医科大学病原生物学与免疫学系,650500 [2]云南省高校热带传染病重点实验室昆明医科大学生物化学与分子生物学系,650500

出　　处：《中国防痨杂志》2021年第8期847-852,共6页Chinese Journal of Antituberculosis

基　　金：云南省自然科学基金[2019FE001(-002)、2017FE467-(001)];国家自然科学基金(81560596、81860644)

摘　　要：结核分枝杆菌具有富含脂质的细胞壁,这种结构有助于结核分枝杆菌维持自身毒力并长期潜伏于宿主体内。脂阿拉伯甘露聚糖是结核分枝杆菌细胞壁中的重要组分,其复杂和独特的结构对结核分枝杆菌的生长、生存和毒力至关重要。作者综述了脂阿拉伯甘露聚糖的结构、生物合成途径、在免疫反应中的作用及在结核病诊断中的应用价值,为其可能作为一种新的结核病诊断生物标志物提供新的视野与思路。Mycobacterium tuberculosis(MTB)cell wall contains rich lipids,which helps to maintain its own virulence and the long-term latent in the host.Lipoarabinomannan(LAM)is an important component in the cell wall of MTB,and its complex and unique structure is crucial for the growth,survival and virulence of MTB.In this review,we summarized the structure,biosynthetic pathway of LAM and its role in immune response as well as its application value in tuberculosis diagnosis.It could provide a new vision and ideas for its potential as a new biomarker for tuberculosis diagnosis.

关 键 词：甘露聚糖类 分枝杆菌 结核 免疫 诊断 

分 类 号：R52[医药卫生—内科学]