HIF-1α、VEGF及AMH在多囊卵巢综合征中的表达及其临床意义  

Expression and clinical significance of HIF-1α,VEGF and AMH in patients with polycystic ovary syndrome

作　　者：秦薇[1] 黄筱竑[1] 黄慧莲 QIN Wei;HUANG Xiao-hong;HUANG Hui-lian(Department of Obstetrics and Gynecology,Huzhou Central Hospital,Huzhou Normal College Affiliated Central Hospital,Huzhou,Zhejiang 313003,China;不详)

机构地区：[1]湖州市中心医院,湖州师范学院附属中心医院妇产科,浙江湖州313003 [2]湖州市中心医院,湖州师范学院附属中心医院中心实验室

出　　处：《中华全科医学》2021年第10期1693-1696,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2019ZH043)。

摘　　要：目的研究缺氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)和抗苗勒管激素(AMH)在多囊卵巢综合征(PCOS)中的表达水平,探讨其临床意义。方法选择2018年6月-2020年6月湖州市中心医院收治的130例PCOS患者为观察组,同期100例健康女性为对照组,采用免疫化学发光法检测卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、睾酮(T)、孕酮(P)和雌二醇(E2)水平,酶联免疫吸附法检测血清HIF-1α、VEGF和AMH水平,分析HIF-1α、VEGF和AMH的相关性及对PCOS的预测价值。结果观察组患者的FSH[(5.81±0.92)mU/mL]、LH[(10.54±0.72)mU/mL]、PRL[(398.55±80.47)ng/mL]、T[(7.76±2.27)nmol/L]、P[(5.29±0.92)nmol/L]、E2[(118.63±42.78)pmol/L]显著高于对照组(t值为3.179、12.150、4.284、11.223、43.724、3.955,均P<0.05)。观察组患者HIF-1α[(163.12±25.17)pg/L]、VEGF[(257.03±30.45)pg/L]和AMH[(7.29±1.02)pg/L]显著高于对照组(t值为42.592、31.612、47.194,均P<0.05)。HIF-1α与VEGF、AMH水平均呈正相关(r=0.811、0.848、0.762,均P<0.05)。血清HIF-1α、VEGF及AMH曲线下面积分别为0.764、0.731、0.742,95%CI分别为0.681~0.852、0.634~0.819、0.649~0.827。结论 PCOS患者HIF-1α、VEGF及AMH水平显著升高,对PCOS具有较高的预测价值,可作为临床诊断的指标。Objective To study the expression of hypoxia-inducible factor-1α(HIF-1α),vascular endothelial growth factor(VEGF)and anti-Mullerian hormone(AMH)in polycystic ovary syndrome(PCOS)and to explore their clinical significance.Methods A total of 130 cases of PCOS patients in our hospital from June 2018 to June 2020 were selected as the observation group,and 100 healthy women were recruited as the control group.The levels of follicle stimulating hormone(FSH),luteinising hormone(LH),prolactin(PRL),testosterone(T),progesterone(P)and estradiol(E2)were measured by immunochemiluminescence.The serum HIF-1α,VEGF and AMH levels were detected by enzyme-linked immunosorbent assay.The correlation between HIF-1α,VEGF and AMH and the predictive value of PCOS clinical significance were analysed.Results The levels of FSH[(5.81±0.92)mU/mL],LH[(10.54±0.72)mU/mL],PRL[(398.55±80.47)ng/mL],T[(7.76±2.27)nmol/L],P[(5.29±0.92)nmol/L]and E2[(118.63±42.78)pmol/L]in the observation group were significantly higher than those in the control group(t=3.179,12.150,4.284,11.223,43.724 and 3.955,all P<0.05).The levels of HIF-1α[(163.12±25.17)pg/L],VEGF[(257.03±30.45)pg/L]and AMH[(7.29±1.02)pg/L]in the observation group were significantly higher than those in the control group(t=42.592,31.612 and 47.194,all P<0.05).HIF-1α was positively correlated with VEGF and AMH levels(r=0.811,0.848 and 0.762,all P<0.05).The areas under the curve of serum HIF-1α,VEGF and AMH were 0.764,0.731 and 0.742,and 95%confidence intervals were 0.681-0.852,0.634-0.819 and 0.649-0.827,respectively.Conclusion The levels of HIF-1α,VEGF and AMH in patients with PCOS are significantly increased,which have high predictive value for PCOS and can be used as clinical diagnostic indicators.

关 键 词：多囊卵巢综合征 低氧诱导因子-1Α 血管内皮生长因子 抗苗勒管激素 

分 类 号：R711.75[医药卫生—妇产科学] R446[医药卫生—临床医学]