丝素蛋白抗菌性修饰在皮肤组织工程中的应用  

Researches on application of silk fibroin with antibacterial modification in skin tissue engineering

作　　者：崔雅婷 马保金 葛少华[1] CUI Yating;MA Baojin;GE Shaohua(Department of Periodontology,School and Hospital of Stomatology,Shandong University,Shandong Key Laboratory of Oral Tissue Regeneration,Shandong Engineering Laboratory far Dental Materials and Oral Tissue Regeneration,Jinan 250012,China)

机构地区：[1]山东大学口腔医学院·口腔医院牙周科,山东省口腔组织再生重点实验室,山东省口腔生物材料与组织再生工程实验室,山东济南250012

出　　处：《口腔医学》2021年第8期737-741,共5页Stomatology

基　　金：国家自然科学基金(81873716)。

摘　　要：丝素蛋白(silk fibroin, SF)是一种天然高分子纤维蛋白,常被用作理想敷料应用于口腔颌面部及全身皮肤创面的修复中。SF具有良好的生物相容性、可降解性和机械性能,可促进创面愈合,但其本身不具备抗菌性。通过不同的抗菌性修饰赋予SF材料抗菌性能已得到广泛的研究和关注。本文对SF抗菌性修饰材料在皮肤组织工程中的应用进行系统性介绍,为今后开展SF抗菌性支架材料研究提供思路和指导。Silk fibroin(SF),as a natural polymer fiber protein,has been used as an ideal dressing in oral maxillofacial and wholeskin wound repairing.Although SF has good biocompatibility,degradability,mechanical properties and the ability to promote healing,it does not possess antibacterial properties.Various antibacterial modifications to impart antibacterial properties to SF materials have received extensive research and attention.This article systematically introduces the application of SF antibacterial modification materials in skin tissue engineering,thus to provide ideas and guidance for future research on SF antibacterial scaffold materials.

关 键 词：丝素蛋白 抗菌性修饰 皮肤组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]