捐精志愿者支原体感染后用药对精液质量的影响  

Effect of medication on semen quality of sperm donors infected with ycoplasma

作　　者：钟恺欣 张欣宗[1] 叶桂芳 林维新 伍欣 罗璐璐[1] 王奇玲[1] ZHONG Kai-xin;ZHANG Xin-zong;VE Gui-fang;LIN Wei-xin;WU Xin;LUO Lu-lu;WANG Qi-ling(Human Sperm Bamk,Department ofAndrology,Family Panning Research Institute of Guangdong Province,National Health and Family Planning Commission Male Reproductive and Cenetic Key Laboratory,Guangzhou 510600,Guangdong,China)

机构地区：[1]国家卫生健康委员会男性生殖与遗传重点实验室、广东省计划生育科学技术研究所男性科、广东省计划生育专科医院人类精子库,广东广州510600

出　　处：《广东医学》2021年第8期888-891,共4页Guangdong Medical Journal

基　　金：广东省医学科研基金项目(A2019336);广州市基础研究计划项目(202002030480);广州市科学研究专项项目(201707010394);广东省计划生育科学技术研究所科研基金项目(S2018002)。

摘　　要：目的评估支原体感染后用药治疗对精液质量的影响。方法统计2016年1月至2019年12月在广东省人类精子库支原体筛选检查阳性的445例志愿者经口服药物治疗前后的精液分析资料,志愿者连续用药2周,停药1周及2个月后再次进行精液检查。比较志愿者用药前、用药后1周、用药后2个月精液质量的变化。结果用药前、用药后1周、用药后2个月精液量分别为(3.85±1.37)mL、(3.81±1.48)mL、(3.79±1.37)mL,差异无统计学意义(P=0.362);用药前后精子浓度分别为(96.98±35.35)×10^(6)·mL^(-1)、(90.18±40.68)×10^(6)·mL^(-1)、(88.57±34.44)×10^(6)·mL^(-1),用药后精子浓度降低,差异有统计学意义(P=0.008);用药前后前向运动精子百分比分别为(60.52±9.45)%、(58.02±12.23)%、(59.41±11.15)%,用药后前向运动精子百分比降低,差异有统计学意义(P=0.004);用药前后非前向运动精子百分比分别为(3.19±1.79)%、(3.31±2.02)%、(3.38±2.19)%,差异无统计学意义(P=0.904);用药前后不动精子百分比分别为(36.28±9.22)%、(38.68±12.10)%、(37.20±11.07)%,用药后不动精子百分比升高,差异有统计学意义(P=0.004);用药前后总精子数分别为(365.06±167.44)×10^(6)、(335.77±184.76)×10^(6)、(324.47±146.87)×10^(6),用药后总精子数降低,差异有统计学意义(P=0.003);用药前后前向运动精子总数分别为(220.76±105.31)×10^(6)、(194.68±112.45)×10^(6)、(193.27±93.29)×10^(6),用药后前向运动精子总数降低,差异有统计学意义(P=0.039)。结论支原体用药治疗对精液质量有较大影响,主要体现在降低精子浓度和精子活力,使不动精子占比增加,对精液量没有显著影响;总精子数和前向运动总精子数显著降低。Objective To evaluate the effect of medication on semen quality after mycoplasma infection.Methods The semen analysis data of 445 volunteers with positive Mycoplasma screening in Guangdong sperm bank from January 2016 to December 2019 were collected before and after oral drug treatment.The volunteers were continuously treated for 2 weeks,and their semen was examined again after 1 week and 2 months.The semen quality of volunteers before medication,1 week after medication,and 2 months after medication were compared.Results The semen volume before treatment,1 week after treatment and 2 months after treatment were(3.85±1.37)mL,(3.81±1.48)mL and(3.79±1.37)mL,respectively(P=0.362).The sperm concentration before and after treatment were(96.98±35.35)×10^(6)·mL^(-1),(90.18±40.68)×10^(6)·mL^(-1) and(88.57±34.44)×10^(6)·mL^(-1),respectively.The sperm concentration significantly decreased after treatment(P=0.008).The percentage of progressive motility sperm before and after treatment were(60.52±9.45)%,(58.02±12.23)%and(59.41±11.15)%,respectively.After treatment,the percentage of forward motile sperm significantly decreased(P=0.004).The percentage of non-progressive motility sperm before and after treatment were(3.19±1.79)%,(3.31±2.02)%,respectively,and the difference was not statistically significant(P=0.904).The percentage of immobile sperm before and after treatment were(36.28±9.22)%,(38.68±12.10)%and(37.20±11.07)%,respectively,and the percentage of immobile sperm significantly increased after treatment(P=0.004).The total sperm count before and after treatment were(365.06±167.44)×10^(6),(335.77±184.76)×10^(6) and(324.47±146.87)×10^(6),respectively.The total sperm count significantly decreased after treatment(P=0.003).The total number of progressive motility sperm before and after treatment were(220.76±105.31)×10^(6),(194.68±112.45)×10^(6) and(193.27±93.29)×10^(6),respectively.The total number of forward motile sperm significantly decreased after treatment(P=0.039).Conclusion The treatment of

关 键 词：支原体感染 用药治疗 精液质量 影响 捐精志愿者 

分 类 号：R699.7[医药卫生—泌尿科学] R588.6[医药卫生—外科学]