槲皮素对糖尿病大鼠肾脏GSK3β信号通路的影响  

Effect of Quercetin on GSK3βSignal Pathway in Kidney of Diabetic Rats

作　　者：王兴红[1] 邓海峰[1] 孙缦利[1] Wang Xinghong;Deng Haifeng;Sun Manli(Luohe Medical College,Luohe 462000)

机构地区：[1]漯河医学高等专科学校,河南漯河462000

出　　处：《中阿科技论坛（中英文）》2021年第9期73-75,共3页China-Arab States Science and Technology Forum

基　　金：2018年度河南省高等学校青年骨干教师培养计划资助项目“槲皮素调控GSK3β信号转导通路影响大鼠糖尿病肾脏疾病发病机制的研究”(2018GGJS258);河南省2017年科技发展计划项目“科技攻关”“槲皮素对糖尿病肾脏疾病大鼠Wnt通路与p38MAPK/NF-κB通路交互作用因子GSK3β调控研究”(1721023610312)。

摘　　要：为了研究槲皮素对链脲佐菌素致糖尿病大鼠肾脏GSK3β信号转导通路的作用,本文采用腹腔一次性注射链脲佐菌素建立糖尿病大鼠模型,并设置正常对照组、糖尿病模型组、槲皮素组,测定各组大鼠肾功能。研究结果表明:槲皮素对糖尿病大鼠肾功能的保护作用可能通过调控肾脏Wnt/β-catenin/GSK3β信号通路。In order to study the effect of quercetin on the GSK3βsignal transduction pathway in the kidneys of streptozotocin-induced diabetic rats,this paper uses a one-time intraperitoneal injection of streptozotocin to establish a diabetic rats model and randomly divide the rats into a control group and a diabetes model group to determine the renal function of rats in each group.The results of the study indicate that the protective effect of quercetin on the renal function of diabetic rats may be related to the regulation of the renal Wnt/β-catenin/GSK3βsignaling pathway.

关 键 词：槲皮素 糖尿病肾病 WNT3A 糖原合成酶激酶3Β Β-CATENIN 

分 类 号：R587[医药卫生—内分泌]