Histidine ameliorates elastase-and lipopolysaccharide-induced lung inflammation by inhibiting the activation of the NLRP3 inflammasome  

作　　者：Qiaoshan Tian Ming Xu Bei He 

机构地区：[1]Department of Respiratory Medicine,Peking University Third Hospital,Beijing 100191,China [2]Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China

出　　处：《Acta Biochimica et Biophysica Sinica》2021年第8期1055-1064,共10页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(Nos.81670034 and 81470235).

摘　　要：Histidine treatment has anti-inflammatory effects on several diseases such as colitis and obesity.We revealed that histidine levels were decreased in the serum of patients with chronic obstructive pulmonary disease(COPD)in our previous study.However,whether histidine confers protection against COPD is unclear.In the present study,we evaluated the protective effects of histidine in a porcine pancreatic elastase-and lipopolysaccharide-induced COPD mouse model.We found that the serum histidine concentration was decreased in COPD mice.Histidine supplementation improved the COPD mouse lung function and reduced the inflammatory cell counts and production of cytokines in bronchoalveolar lavage fluid.In addition,histidine treatment ameliorated lung inflammation by inhibiting the nucleotide-binding oligomerization domain-like receptor(NLR)family pyrin domain-containing 3 inflammasome activation both in vivo and in vitro.Furthermore,we found that the potential anti-inflammatory mechanism involved the upregulation of silent information regulator factor 2-related enzyme 1.These results suggest that histidine may be a valuable therapeutic target for COPD.

关 键 词：HISTIDINE COPD inflammation NLRP3 SIRT1 

分 类 号：R563.1[医药卫生—呼吸系统]