某复方口服液对小鼠酒精性肝损伤的辅助保护作用研究  

Auxiliary Protection of A Compound Oral Liquidon Alcoholic Liver Injury in Mice

作　　者：熊亚茹 张莹莹[1] 崔鲁炜 胡余明[1] XIONG Yaru;ZHANG Yingying;CUI Luwei;HU Yuming(Hunan Provincial Center for Disease Control and Prevention,Changsha 410005,Hunan Province,China.)

机构地区：[1]湖南省疾病预防控制中心,长沙410005

出　　处：《预防医学情报杂志》2021年第8期1164-1167,共4页Journal of Preventive Medicine Information

摘　　要：目的研究某复方口服液对小鼠酒精性肝损伤的辅助保护作用。方法将实验小鼠随机分为低、中、高剂量组及空白/模型对照组,30 d后以乙醇造成急性肝损伤模型,测定各组小鼠肝脏丙二醇(MDA)、还原性谷胱甘肽(GSH)及甘油三酯(TG)含量,同时进行肝脏病理组织学检查,采用t检验分析模型对照组与不同剂量组之间的差异,P<0.05为差异具有统计学意义。结果高剂量组小鼠肝脏的TG含量及脂肪变性程度明显低于模型对照组(P<0.05),GSH含量明显高于模型对照组(P<0.05)。结论该复方口服液对小鼠酒精性肝损伤具有一定的辅助保护作用。Objective to investigate the auxiliary protection of a compound oral liquid on alcoholic liver injury in mice.Methods The experimental mice were randomly divided into low,medium,high-dose groups and blank/model control group,acute liver injury model was fabricated using ethanol after 30 days,the contents of propylene glycol(MDA),reduced glutathione(GSH)and triglyceride(TG)of the liver were measured for each groups,meanwhile,liver histopathological examination was also conducted.The t test was employed in this study to analyze the differences between groups,and a P value less than 0.05 was considered to be statistically significant.Results The content of TG and the degree of steatosis of the liver in the high-dose group were significantly lower than that of the model control group(P<0.05),and the content of GSH was significantly higher than that of the model control group(P<0.05).Conclusion This compound oral liquid has auxiliary protection on alcoholic liver injury in mice.

关 键 词：动物试验 酒精性肝损伤 甘油三酯 谷胱甘肽 

分 类 号：R114[医药卫生—卫生毒理学]