"初免-吸引"免疫策略的研究进展  

Research progress on"prime and pull"immunization strategy

作　　者：沈妍希(综述) 马永平(审校)[1] Shen Yanxi;Ma Yongping(Research Center of Molecular Medicine and Cancer,Chongqing Medical University School of Basic Medicine,Chongqing 400016,China)

机构地区：[1]重庆医科大学基础医学院分子医学与肿瘤研究中心,400016

出　　处：《国际生物制品学杂志》2021年第4期218-223,共6页International Journal of Biologicals

基　　金：国家自然科学基金(30972585)。

摘　　要："初免-吸引"免疫策略是指经胃肠外疫苗初次免疫后,通过局部使用T细胞引诱剂,在病原体进入的主要部位如生殖道、气道和肠道等招募和建立组织驻留记忆性T细胞,可应用到病毒或细菌等感染黏膜引起的疾病中,建立长期黏膜免疫。此文就该免疫策略在病毒、细菌、衣原体及螺旋体感染性疾病领域的研究进展进行综述,以期为疫苗研发提供新的思路。The"prime and pull"immunization strategy refers to the recruitment and establishment of tissue resident memory T cells in the main regions of pathogen entry,such as reproductive tract,airway and intestine,through topical application of T cell attractants after the prime immunization of parenteral vaccines.This strategy can be applied to establish long-term mucosal immunity against diseases with mucosal infection from viruses,bacteria,etc.This article reviews the research progress of this immunization strategy in viral,bacterial,chlamydial and spirochetal infectious diseases,in order to provide new ideas for vaccine development.

关 键 词：初免-吸引 免疫 记忆性T细胞 疫苗 

分 类 号：R392.9[医药卫生—免疫学]