自拟二仙汤加减治疗冲任失调型乳腺增生症30例临床观察  

Obsveration of Curative Effect of Modified Erxian Decotion on Breast Hyper Hyperplasia with the Syndrome Pattern of Chongren Imbalance and the Effect of Modified Erxian Decoction on Serum E_(2),P and PRL

作　　者：黄子艳 吴佳丽 邹盛 郑向龙 王雨欢 赵燕灵 王万春[2] HUANG Ziyan;WU Jiali;ZOU Sheng;ZHENG Xianglong;WANG Yuhuan;ZHAO Yanling;WANG Wanchun(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang330019,China)

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西中医药大学附属医院,江西南昌330019

出　　处：《中国民族民间医药》2021年第16期107-111,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:观察自拟二仙汤加减治疗冲任失调型乳腺增生症的显愈率及对血清雌二醇(E_(2))、催乳素(PRL)、孕酮(P)的影响。并评价其临床不良反应。方法:选取门诊60例冲任失调型乳腺增生症患者作为研究对象,将其按随机数字表分为对照组30例与观察组30例。对照组给予枸橼酸他莫昔芬片治疗,观察组给予二仙汤加减治疗。治疗8周后,观察治疗前、治疗后及停药后4周两组疼痛评分(PRI、VAS、PPI、SF-MPQ),肿块范围、大小、质地评分及血清雌二醇(E_(2))、催乳素(PRL)、孕酮(P)水平变化,并比较两组的显愈率。结果:①治疗后和停药4周后,两组疼痛评分(PRI、VAS、PPI、SF-MPQ),肿块范围、大小、质地评分与治疗前相比均降低,且差异有统计学意义(P<0.05);②两组治疗后及停药4周后与治疗前比较,血清P水平均升高,且差异有统计学意义(P<0.05),E_(2)、PRL水平均降低,且差异有统计学意义(P<0.05);③治疗后对照组显愈率为40.00%,观察组为70.00%,差异有统计学意义(P<0.01)。结论:自拟二仙汤加减治疗冲任失调型乳腺增生患者显愈率高于枸橼酸他莫昔芬片,能有效减轻疼痛及消块,调节患者E_(2)、P、PRL代谢水平,且不良反应小,值得推广。Objective To observe the effective rate of Modified Erxian Decoction in the treatment of breast hyperplasia with the syndrome pattern of chongren imbalance and its effect on serum estradiol(E_(2)),prolactin(PRL)and progesterone(P).And evaluate its clinical safety.Methods 60 cases of breast hyperplasia with the syndrome pattern of chongren imbalance were selected as the subjects of the study,Whichare divided into control group and observation group according to the random number table.The control group was given tamoxifen citrate tablets,and the observation group was given Modified Erxian Decoction treatment.After 8 weeks of treatment,pain score(PRI,VAS,PPI,SF-MPQ),lump range and size,texture score,serum estradiol(E_(2)),prolactin(PRL),and progesterone(P)levels of the 2 groups were observed before treatment,after treatment,and 4 weeks after drug withdrawal,and the significant efficiency of the 2 groups was compared.Results①after treatment and 4 weeks after drug withdrawal,pain scores(PRI,VAS,PPI,sf-mpq),lump range and size and texture scores of patients in both groups were reduced compared with those before treatment,and there were statistically significant differences(P<0.05).②Compared with before treatment,after treatment and 4 weeks after drug withdrawal,serum P levels of both groups were increased(P<0.05),while E_(2) and PRL levels were decreased(P<0.05).③After treatment,the effective rate was 70.00%in the observation group and 40.00%in the control group,showing statistical difference(P<0.01).Conclusion The effective rate of Modified Erxian Decoction in the treatment of patients with breast hyperplasia with the syndrome pattern of chongren imbalance was higher than that of tamoxifen citrate tablets,which can effectively reduce pain and eliminate lumps,regulate the metabolic level of E_(2),P and PRL in patients,and has fewer side effects,which is worthy of promotion.

关 键 词：二仙汤加减 冲任失调证 乳腺增生 E_(2) P PRL 

分 类 号：R655.8[医药卫生—外科学]