创伤性脑损伤后智商值与P300的相关性研究  

A study of correlation between P300 and IQ after traumatic brain injury

作　　者：饶广勋[1] 卢秋莹 刘子龙[1] 梁曼[1] 朱方成 Rao Guangxun;Lu Qiuying;Liu Zilong;Liang Man;Zhu Fangcheng(Department of Forensic Medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei 430030;School of Basic Medicine,Hubei University of Medicine,Shiyan,Hubei 442000)

机构地区：[1]华中科技大学同济医学院法医学系,湖北武汉430030 [2]湖北医药学院基础医学院,湖北十堰442000

出　　处：《中国法医学杂志》2021年第4期360-363,共4页Chinese Journal of Forensic Medicine

基　　金：华中科技大学2019年实验技术研究项目(2019-54);湖北医药学院人才启动基金计划项目(2019QDJZR15)。

摘　　要：目的通过探索创伤性脑损伤(TBI)伤者智商值(IQ)与听觉P300的相关性,寻找能够反映伤者真实智能状态的评价指标。方法征集需进行智能损害司法鉴定的TBI伤者,进行二项必选数字记忆测验,选取测验合作者427名,分别进行流行病学统计、中国修订韦氏成人智力量表(WAIS-RC)和P300检测,分析IQ与被试者基本情况及P300各成分之间的相关性。结果年龄、受教育程度及TBI的严重程度对被试者的智能状态均有一定程度的影响;智能损害程度越严重,TBI伤者的P3波潜伏期和N2波潜伏期越长(P<0.01),IQ和P3波潜伏期之间呈显著负相关(r=-0.71,P<0.01),IQ和N2波潜伏期之间表现出弱负相关(r=-0.32,P<0.01)。结论 P3波潜伏期比N2波潜伏期更能代表TBI伤者的真实智能水平,可作为评估脑外伤后智能损害的重要参考指标。Objective Looking for an objective indicator that can reflect the intelligence state of traumatic brain injury(TBI) patient by exploring the correlation between intelligence quotient and auditory P300. Methods The TBI injured involved in forensic psychiatric identification were recruited for Binomial Forced-Choice Digit Memory Test, and 427 cases that have passed the test were arranged to be accessed by epidemiological statistics, a Chinese Revised Wechsler Adult Intelligence Scale(WAIS-RC) as well as event-related potentials(ERPs) P300 examination. The correlation of IQ and P300 components were evaluated. Results All of age, education and the severity of TBI have a certain degree of influence on the intelligence status of the subjects;the more severe the degree of intelligence deficiency, the longer P3 and N2 latency of the subjects(P<0.01), there was a significant negative correlation between IQ and P3 latency(r=-0.71, P<0.01), and a weaker significant negative correlation between IQ and N2 latency(r=-0.32, P<0.01). Conclusion The P3 latency is more representative of the intelligence status of the TBI injured than N2, and can be used as an important indicator of IQ change incurred by brain injuries.

关 键 词：法医精神病学 创伤性脑损伤 事件相关电位 P300 智商 

分 类 号：DF795.2[医药卫生—法医学]