益生菌通过肠-皮肤轴改善皮肤疾病  

Probiotics in ameliorating skin diseases through gut-skin axis

作　　者：王艺蓉 梅迪 郭莉 孙同毅[1] 高媛媛 WANG Yirong;MEI Di;GUO Li;SUN Tongyi;GAO Yuanyuan(Shandong Key Laboratory of Proteins and Peptides Pharmaceutical Engineering,Shandong Universities Key Laboratory of Biopharmaceuticals,School of Life Science and Technology,Weifang Medical University,Weifang 261053,China;School of Pharmacy,Weifang Medical University,Weifang 261053,China)

机构地区：[1]潍坊医学院生命科学与技术学院,山东省蛋白质与多肽药物工程实验室,山东省高校生物药物重点实验室,潍坊261053 [2]山东潍坊医学院药学院,潍坊261053

出　　处：《生命的化学》2021年第6期1288-1294,共7页Chemistry of Life

基　　金：山东省高等学校青创科技支持计划项目(2019KJM003)。

摘　　要：肠道微生物区系是肠-皮肤轴的主要调节因子,可以将肠道与炎症性皮肤病联系起来。调节肠道微生物区系可改善肠道微环境,进而影响皮肤健康。虽然越来越多的证据证明了肠-皮肤轴的存在,但他们之间的作用机制还有待阐明。本文总结了肠道微生物与三种常见皮肤病——痤疮、特异性皮炎、银屑病相互作用的最新进展,与此同时提出了补充益生菌和改善饮食成分作为潜在参与者改善皮肤健康的策略。Intestinal microflora is a major regulator of the gut-skin axis, which can link the gut with inflammatory skin diseases and improve the intestinal microenvironment by regulating the intestinal microflora in the body to improve the skin condition. Although there is increasing evidence for the existence of the gut-skin axis, the mechanism of action between them remains to be elucidated. This review summarized the latest developments in the interaction of a series of microorganisms with three common skin diseases including acne, specific dermatitis and psoriasis, as well as supplementing probiotics and improving dietary ingredients as strategies for potential participants to improve skin health.

关 键 词：肠-皮肤轴 皮肤 肠道 益生菌 饮食 

分 类 号：R751[医药卫生—皮肤病学与性病学]