DPL结合羟氯喹治疗对玫瑰痤疮患者疗效和红斑血管扩张评分的影响及患者生活质量指数影响因素Logistic分析  

The Effect of DPL Combined with Hydroxychloroquine on Rosacea Patients'Efficacy,Erythema Vasodilation Score and the Logistic Analysis of Influencing Factors of Quality of Life Index in Patients

作　　者：施伟伟[1] 花志祥[1] 黄红娟[1] 范向华[1] SHI Wei-wei;HUA Zhi-xiang;HUANG Hong-juan;FAN Xiang-hua(Department of Dermatology,Nantong First People's Hospital,Nantong 226000,Jiangsu,China)

机构地区：[1]南通市第一人民医院皮肤科,江苏南通226000

出　　处：《中国美容医学》2021年第8期63-67,共5页Chinese Journal of Aesthetic Medicine

基　　金：南通市卫生和计划生育委员会科研项目(编号:WKZL2018085)。

摘　　要：目的:研究窄谱强脉冲光(DPL)结合羟氯喹用药对玫瑰痤疮患者疗效和红斑血管扩张评分的影响,Logistic分析生活质量指数影响因素。方法:选取笔者医院2017年6月-2019年6月收治的67例玫瑰痤疮患者,依据随机数字表法分为对照组(n=33)以及观察组(n=34)。对照组采用羟氯喹治疗,观察组采用DPL结合羟氯喹治疗。比较两组患者临床疗效以及红斑血管扩张评分和皮肤病生活质量指数(DLQI),并采用Logistic分析患者生活质量指数影响因素。结果:治疗后,两组患者的红斑毛细血管扩张、丘疹脓疱、瘙痒评分均显著降低,其中观察组治疗后各评分显著低于对照组,且观察组治疗有效率显著高于对照组(91.18%vs 69.70%),差异具有统计学意义(P<0.05)。治疗后,两组患者DLQI评分均显著降低,其中观察组治疗后不同时间点(4周、8周、12周)各评分显著低于对照组,差异有统计学意义(P<0.05)。单因素分析显示,女性DLQI评分高于男性,低年龄(≤30岁)患者DLQI评分高于高年龄患者(>30岁),未婚患者高于已婚患者,丘疹型患者高于红斑型患者,差异具有统计学意义(P<0.05)。Logistic回归分析表明显示,性别、年龄、婚姻情况以及分型均是影响患者生活质量的危险因素(P<0.05)。结论:DPL结合羟氯喹可有效降低红斑血管扩张评分,改善患者生活质量,提高治疗效果。性别、年龄、婚姻情况以及分型均是影响玫瑰痤疮患者生活质量的危险因素。Objective To study the effect of DPL combined with hydroxychloroquine on rosacea patients'efficacy and erythema vasodilation score,and to analyze the influencing factors of quality of life index by Logistic.Methods 67 patients with rosacea admitted to our hospital from June 2017 to June 2019 were divided into control group(33 cases)and observation group(34 cases)according to the method of random number table.The control group was treated with hydroxychloroquine,and the observation group was treated with DPL and hydroxychloroquine.The clinical efficacy,erythema vasodilation score and skin disease quality of life index(DLQI)were compared between the two groups,and the influencing factors of DLQI were analyzed by Logistic.Results After treatment,the scores of capillaries dilation,pimples and pustules,pruritus in the two groups were significantly reduced,and the scores in the observation group were significantly lower than those in the control group,and the effective rate in the observation group was significantly higher than that in the control group(91.18%vs 69.70%),with significant difference(P<0.05).After treatment,the DLQI scores of the two groups were significantly reduced,and the scores of the observation group at different time points(4 weeks,8 weeks,12 weeks)were significantly lower than those of the control group,with significant difference(P<0.05).Single factor analysis showed that the DLQI score of female patients was higher than that of male patients,the DLQI score of patients with low age(<30 years old)was higher than that of patients with high age(>30 years old),that of unmarried patients was higher than that of married patients,and that of patients with papule type was higher than that of patients with erythema type(P<0.05).Logistic regression analysis showed that gender,age,marriage and classification were all risk factors for quality of life(P<0.05).Conclusion Sex,age,marriage and classification are all risk factors of rosacea patients'quality of life.DPL combined with hydroxychloroquine can effecti

关 键 词：窄谱强脉冲光 羟氯喹 玫瑰痤疮 红斑血管扩张评分 生活质量指数 

分 类 号：R758.734[医药卫生—皮肤病学与性病学]