Chronic active Epstein-Barr virus infection treated with PEGaspargase: A case report  

作　　者：De-Li Song Jing-Shi Wang Lei-Lei Chen Zhao Wang 

机构地区：[1]Department of Hematology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China

出　　处：《World Journal of Clinical Cases》2021年第26期7845-7849,共5页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No.81871633;Beijing Natural Science Foundation,No.7181003;Beijing Municipal Administration of Hospitals’Ascent Plan,No.DFL20180101.

摘　　要：BACKGROUND Chronic active Epstein-Barr virus infection(EBV)is a systemic EBV-positive lymphoproliferative disease,which may lead to fatal illness.There is currently no standard treatment regimen for chronic active EBV(CAEBV),and hematopoietic stem cell transplantation is the only effective treatment.We here report a CAEBV patient treated with PEG-aspargase,who achieved negative EBV-DNA.CASE SUMMARY A 33-year-old female Chinese patient who had fever for approximately 3 mo was admitted to our hospital in December 2017.EBV-DNA was positive with a high copy number.She was diagnosed with chronic active EB virus infection.PEGaspargase was administered at a dose of 1500 U/m2 at a 14-d interval,resulting in eradication of EBV for more than 6 mo.The effect of PEG-aspargase in this patient was excellent.CONCLUSION A chemotherapy regimen containing PEG-aspargase for CAEBV may be further considered.

关 键 词：Chronic active Epstein-Barr virus infection PEG-aspargase CHEMOTHERAPY L-ASPARAGINASE Case report 

分 类 号：R551.2[医药卫生—血液循环系统疾病]