COOK宫颈扩张球囊和欣普贝生在妊娠期高血压孕妇引产中的应用对比  

Effect of COOK ripening balloon vs.simpubexon on labor induction of pregnant women with gestational hypertension

作　　者：江梅花 陈先侠[1] JIANG Meihua;CHEN Xianxia(Maternal and Child Health Care Hospital,Anhui Medical University,Hefei 230000,China)

机构地区：[1]安徽医科大学附属妇幼保健院,合肥230000

出　　处：《实用医学杂志》2021年第17期2257-2261,共5页The Journal of Practical Medicine

基　　金：安徽省2018年度重点研究与开发计划项目(编号:1804h08020295)。

摘　　要：目的探讨COOK子宫颈扩张球囊(COOK cervical ripening balloon,CCRB)和欣普贝生(地诺前列酮)在孕晚期妊娠期高血压孕妇中引产的安全性、有效性。方法回顾分析2018年9月至2020年9月安徽省妇幼保健院收治的有引产指证且宫颈Bishop评分<6分的足月妊娠期高血压孕妇,CCRB组104例,欣普贝生组64例。比较两种方法的促宫颈成熟效果、引产效果、引产过程中血压波动情况以及不良母婴并发症等情况。结果欣普贝生促宫颈成熟效果优于CCRB。欣普贝生组引产前宫颈Bishop评分低于CCRB组(P<0.05),但两组引产后宫颈Bishop评分及促宫颈成熟的总有效率差异无统计学意义(P>0.05);欣普贝生组干预至12 h内阴道分娩率高于CCRB组(P<0.05);欣普贝生组临产后血压波动最大值明显高于CCRB组(P<0.05),但两组不良分娩并发症及新生儿窒息发生率差异无统计学意义(P>0.05)。欣普贝生较CCRB易引起宫缩过强或过频不良反应(P<0.05)。结论对于足月妊娠期高血压孕妇,使用欣普贝生和CCRB引产均展现了安全和高效的性能,当宫颈Bishop评分较低时,欣普贝生促宫颈成熟较CCRB更加有效,但易引起子宫过度刺激和较大血压波动,须严密监护下使用。Objective To explore the safety and effectiveness of Cook cervical ripening balloon(CCRB)and Simpubexant(dinoprostone)in inducing labor in pregnant women with hypertension in the third trimester.Methods A retrospective analysis was conducted to research into the data of full-term pregnant women with hypertension during pregnancy who were admitted to Anhui Maternity and Child Health Hospital from September 2018 to September 2020 with indications of labor induction and with a cervical Bishop score of<6 points 104 cases were enrolled in the CCRB group and another 64 cases in the Simpubesheng group.The effects of promoted cervical ripening,the effect of labor induction,the fluctuation of blood pressure during labor induction,and the adverse maternal and infant complications of the two methods were compared.Results Simpubesheng was more effective in promoting cervical ripening than CCRB.The Bishop score of the cervix before the induction of labor in the Simpbeson group was significantly lower than that of the CCRB group(P<0.05),but there was no significant difference between the two groups in the Bishop score of the cervix and the total effective rate of cervical ripening after induction of labor(P>0.05).T The rate of vaginal delivery within 12 hours of intervention was significantly higher than that in the CCRB group(P<0.05).The maximum blood pressure fluctuation in the Simpubeson group was significantly higher than that in the CCRB group(P<0.05),but the two groups had adverse delivery complications and neonatal asphyxia.There was no statistical difference in incidence(P>0.05).Compared with CCRB,Simpubexen was more likely to cause side effects of excessive or frequent uterine contractions(P<0.05).Conclusion For pregnant women with hypertension during full-term pregnancy,Simpubexen and CCRB both is safe and effective in labor induction.When the cervical Bishop score is low,Simpubexen is more effective than CCRB in promoting cervical ripening,but it is easier.It can cause excessive uterine stimulation and large blood p

关 键 词：COOK宫颈扩张球囊 欣普贝生 妊娠期高血压 促宫颈成熟效果 

分 类 号：R719.3[医药卫生—妇产科学]