小青龙汤合小柴胡汤治疗肺气虚寒型变应性鼻炎患者疗效与调节Treg细胞相关因子的研究  

Efficacy of Erxiao decoction on allergic rhinitis in patients with pulmonary qi deficiency and cold pattern and its effect on regulatory Treg cell-related factors:a randomized controlled trial

作　　者：肖阁敏[1] 郭文海[1] 戴敏[1] 杨跃武[1] XIAO Gemin;GUO Wenhai;DAI Min;YANG Yuewu(Yang Hongzhi Inheritance Studio,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)

机构地区：[1]广东省名中医杨宏志传承工作室,中山大学附属第三医院中医科,广州510630

出　　处：《实用医学杂志》2021年第17期2287-2291,共5页The Journal of Practical Medicine

摘　　要：目的探究自拟二小汤(小青龙汤合小柴胡汤)治疗肺气虚寒型变应性鼻炎患者疗效及其对调节性T细胞(regulatory cells,Tregs)相关因子的作用。方法将64例患者随机分为观察组、对照组各32例。观察组应用自拟二小汤治疗,对照组采用氯雷他定片治疗。治疗28 d后,观察两组症状评分、血清中转化生长因子-β(transforming growth factor-β,TGF-β)、白介素10(interleukin-10,IL-10)、白细胞介素17(interleukin 17,IL-17)含量以及生活质量。结果治疗后,观察组的打喷嚏、鼻痒、鼻塞症状评分低于对照组(P<0.05);观察组血清中TGF-β、IL-10高于对照组(P<0.05),IL-17低于对照组(P<0.05);观察组鼻结膜炎生存量表(rhinoconjunctivitis quality of life scale,RQLQ评分)优于对照组(P<0.05)。结论自拟二小汤可以改善变应性鼻炎临床症状,提升患者血清中TGF-β、IL-10的含量,降低IL-17的含量,明显改善患者生活质量,效果全面优于氯雷他定片,值得临床进一步研究其机理及远期疗效。Objective To explore the therapeutic effect of Erxiao decoction(Xiaoqinglong decoction and Xiaochaihu decoction)on allergic rhinitis(AR)in patients with lung qi deficiency cold patten and the role of regulatory cells(Tregs)related factors.Methods A total of 64 patients were randomly assigned into observation group(n=32)and control group(n=32).The observation group was treated with Erxiao decoction,and the control group was treated with Loratadine tablets.After 28 days of treatment,the symptom score and serum transforming growth factor including transforming growth factor-β,TGF-β,Interleukin-10(IL-10),interleukin-17(IL-17)content and quality of life were observed.Results The scores of sneezing,nasal itching and nasal congestion in the observation group were significantly lower than those in the control group(P<0.05).In the observation group,the levels of TGF-βin serum were significantly higher than those in the control group,IL-10 was significantly higher than that of the control group(P<0.05),and IL-17 was significantly lower than that of the control group(P<0.05).The rhinoconjunctivitis quality of life scale(RQLQ score)of the observation group was significantly better than that of the control group(P<0.05).Conclusion Erxiao decoction could relieve the symptoms of AR and increase the serum TGF-βand IL-10.It is worthy of further study on its mechanism and long-term efficacy.

关 键 词：变应性鼻炎 小柴胡汤 小青龙汤 TREG 随机对照试验 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]