七白散加减联合调Q激光治疗气滞血瘀型黄褐斑疗效及对血清中丙二醛、脂质过氧化物及超氧化物歧化酶含量影响  

Effect of modified Qibaisan combined with Q-switched laser on chloasma of qi stagnation and blood stasis type and its effect on serum MDA,LPO and SOD content

作　　者：张翠侠 陈桂升[1] 管志强 李敬果 唐志铭 王蒙蒙[1] 单霄 屈雯 车明 段彦娟 ZHANG Cuixia;CHEN Guisheng;GUAN Zhiqiang;LI Jingguo;TANG Zhiming;WANG Mengmeng;SHAN Xiao;QU Wen;CHE Ming;DUAN Yanjuan(Xuzhou Hospital of Traditional Chinese Medicine,Nanjing University of Traditiona Chinese Medicine,Xuzhou 221000,China;不详)

机构地区：[1]南京中医药大学附属徐州市中医院,江苏徐州221000 [2]徐州市第一人民医院,江苏徐州221000 [3]上海市第七人民医院,上海200000

出　　处：《实用医学杂志》2021年第17期2292-2295,共4页The Journal of Practical Medicine

基　　金：上海市浦东新区重点学科建设项目(编号:PW-Zxq2017-16)。

摘　　要：目的七白散加减联合调Q激光治疗气滞血瘀型黄褐斑疗效及对血清中丙二醛(MDA)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)水平的影响。方法将126例入组患者采用数字表法随机分为治疗组和对照1、2组。治疗组予以七白散加减联合调Q激光联合治疗;对照1组予以调Q激光治疗;对照2组予以七白散加减治疗。以1个月为1个疗程,共3个疗程,疗程结束后进行疗效判定。结果治疗组皮损改善明显,有效率为92.8%(39/42),对照1组有效率为64.2%(27/42),对照2组有效率为71.4%(30/42),三组有效率差异有统计学意义(P<0.01)。治疗组较两对照组患者血清MDA/LPO下降明显,SOD显著升高(P<0.01)。结论七白散加减联合调Q激光对黄褐斑患者具有很好的疗效,值得临床推广应用。Objective To study the clinical effect of modified Qibaisan combined with Q-switched laser on chloasma of qi stagnation and blood stasis type via investigating its effect on malondialdehyde(MDA),lipid peroxide(LPO)and superoxide dismutase(SOD)in serum.Methods One hundred and twenty-six patients were randomly divided into treatment groups,control group 1 and 2 using the random digital table,treated with modified Qibaisan combined with Q-switched laser treatment,Q-switched laser alone and modified Qibaisan alone all for three treatment courses,one month as one course,respectively.At the end of the courses,the three groups were compared in terms of the curative effect.Results The skin lesions in treatment group were significantly improved,with the effective rate of 92.8%(39/42),while the effective rates of control groups 1 and 2 was 64.2%(27/42)and 71.4%(30/42),respectively.The differences in the effective rate between the three groups were statistically significant(P<0.01).The serum MDA/LPO of treatment group was significantly lower than that of control group 1 or 2,and the SOD was significantly increased(P<0.01).Conclusion Modified Qibaisan combined with Q-switched laser is more effective in treatment of patients with chloasma,and it is worthy of clinical application.

关 键 词：七白散加减 调Q激光 黄褐斑 丙二醛 脂质过氧化物 超氧化物歧化酶 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]